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- Table of Contents
ERBB3 Antibodies
AND ERBB3 ELISA kits, ERBB3 Proteins
Many biological assays use antibodies to detect ERBB3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ERBB3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ERBB3 antibodies...
Designing a Western blot for ERBB3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ERBB3 Western Blot GuideERBB3 Infographic by Boster Bio
All ERBB3 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$499
Cat # EK1398
96 wells/kit, with removable strips.
Cat # EK1398
96 wells/kit, with removable strips.
Human
IP, IF, ICC, WB
$370
Cat # P00539
100 μl/vial
Cat # P00539
100 μl/vial
Human, Mouse, Rat
ELISA, IP, IF, WB
$146
Cat # M00539-10
20μL, 40μL, 100μL, 200μL
Cat # M00539-10
20μL, 40μL, 100μL, 200μL
Human, Rat
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00539-4
100 μg
Cat # M00539-4
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00539-7
100 μg
Cat # M00539-7
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00539-6
100 μg
Cat # M00539-6
100 μg
Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00539-5
100 μg
Cat # M00539-5
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00539-9
100 μg
Cat # M00539-9
100 μg
Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00539-8
100 μg
Cat # M00539-8
100 μg
Human, Mouse, Rat
ELISA
$540
Cat # EKC2631
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2631
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1271
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1271
1 kit, containing one 96-well plate and all necessary reagents
ERBB3 Overview
Facts about Receptor tyrosine-protein kinase erbB-3.
Receptor tyrosine-protein kinase erbB-3 (ERBB3)
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is triggered by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778).
May also be triggered by CSPG5 (PubMed:15358134). .
Gene Information
| Human | |
|---|---|
| Gene Name: | ERBB3 |
| Uniprot: | P21860 |
| Entrez: | 2065 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
c-erbB3; EC 2.7.10; EC 2.7.10.1; ErbB3; ErbB-3; erbB3-S; HER3; HER3c-erbB-3; LCCS2; lethal congenital contracture syndrome 2; MDA-BF-1; MGC88033; p180-ErbB3; p45-sErbB3; p85-sErbB3; Proto-oncogene-like protein c-ErbB-3; receptor tyrosine-protein kinase erbB-3; Tyrosine kinase-type cell surface receptor HER3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
Molecular Weight
Mass (kDA):
148.098 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q13.2 |
| Sequence: | 12; NC_000012.12 (56080108..56103505) |
Tissue Specificity
Epithelial tissues and brain.
Subcellular Localizations
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Malignant Paraganglionic Neoplasm
- Neoplasm Metastasis
- Adenocarcinoma
- Cell Invasion
- Nervousness
- Lung Neoplasms
- Malignant Neoplasm Of Lung
Interacting Proteins
- ABL2
- CRK
- CRKL
- EGFR
- ERBB2
- ERBB4
- GRB2
- GRB7
- HCK
- HSP90AB1
Pathways
- Cell Proliferation
- Cell Growth
- Cell Cycle
- Localization
- Pathogenesis
- Regeneration
- Myelination
- Angiogenesis
- Cell Migration
- Cell Death
- Secretion
- Schwann Cell Proliferation
- Endocytosis
PTMs
- Phosphorylation
- Cleavage
- Ubiquitination
- Glycosylation
- Dephosphorylation
- Iodination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ERBB3
bosterbio.com/bosterbio-gene-info-cards/ERBB3
References
PMID: 2687875 by Kraus M.H., et al. Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors.
PMID: 2164210 by Plowman G.D., et al. Molecular cloning and expression of an additional epidermal growth factor receptor-related gene.