DNA repair protein complementing XP-G cells (ERCC5)

Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER).

Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled fix of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too.