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- Table of Contents
ERCC5 Antibodies
AND ERCC5 ELISA kits, ERCC5 Proteins
Many biological assays use antibodies to detect ERCC5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ERCC5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ERCC5 antibodies...
Designing an IHC experiment for ERCC5? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the ERCC5 IHC GuideERCC5 Infographic by Boster Bio
All ERCC5 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01770-2
100 μg/vial
Cat # A01770-2
100 μg/vial
Human
ELISA
$480
Cat # EKC1703
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1703
1 kit, containing one 96-well plate and all necessary reagents
ERCC5 Overview
Facts about DNA repair protein complementing XP-G cells.
DNA repair protein complementing XP-G cells (ERCC5)
Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER).
Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled fix of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too.
Gene Information
| Human | |
|---|---|
| Gene Name: | ERCC5 |
| Uniprot: | P28715 |
| Entrez: | 2073 |
Family
| Belongs to: |
|---|
| XPG/RAD2 endonuclease family |
Alternative Names
COFS3; DNA excision repair protein ERCC-5; DNA repair protein complementing XP-G cells; EC 3.1; ERCM2; excision repair cross-complementing rodent repair deficiency, complementationgroup 5; excision repair protein; xeroderma pigmentosum complementation group G protein; Xeroderma pigmentosum group G-complementing protein; xeroderma pigmentosum, complementation group G; XPGC; XPG-complementing protein; XPGUVDR
Molecular Weight
Mass (kDA):
133.108 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 13q33.1 |
| Sequence: | 13; NC_000013.11 (102846032..102875995) |
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Xeroderma Pigmentosum
- Xeroderma
- Malignant Neoplasm Of Lung
- Carcinoma
- Lung Neoplasms
- Xeroderma Pigmentosum, Group G
- Malignant Neoplasm Of Breast
- Malignant Squamous Cell Neoplasm
- Cholangiocarcinoma
- Cytogenetic Abnormality
- Head And Neck Neoplasms
Interacting Proteins
- GADD45A
Pathways
- Dna Repair
- Dna Excision
- Cell Proliferation
- Mismatch Repair
- Cell Cycle
- Double-strand Break Repair
- Localization
- Transport
- Reverse Transcription
- Translation
- Nucleotide-excision Repair
- Drug Resistance
- Cell Death
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ERCC5
bosterbio.com/bosterbio-gene-info-cards/ERCC5
References
PMID: 8483504 by Scherly D., et al. Complementation of the DNA repair defect in Xeroderma pigmentosum group G cells by a human cDNA related to yeast RAD2.
PMID: 7510366 by Shiomi T., et al. An ERCC5 gene with homology to yeast RAD2 is involved in group G Xeroderma pigmentosum.