Erlin-1 Antibodies

AND ERLIN1 ELISA kits, Erlin-1 Proteins

Many biological assays use antibodies to detect Erlin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Erlin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Erlin-1 antibodies...

We validate the specificity of these antibodies to Erlin-1 by testing them on tissues known to express ERLIN1 positively and negatively. Browse below to find the ERLIN1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ERLIN1 Infographic by Boster Bio

All ERLIN1 Products

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Specificity

Applications

Price

ERLIN1 (NM_006459) Human Recombinant Protein

Coomassie blue staining of purified ERLIN1 protein

$1249
Cat # PROTO75477
20 µg

Anti-ERLIN1 Mouse Monoclonal Antibody [Clone ID: OTI4B1]

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ERLIN1 (Right lane) cDNA for 48 hrs and lysed

Western blot analysis of extracts (35ug) from 4 different cell lines by using anti-ERLIN1 monoclonal antibody (1:500)

Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-ERLIN1 mouse monoclonal antibody

Human, Mouse, Rat

IHC, WB

$523
Cat # M08034
100 µl

Anti-ERLIN1 Antibody Picoband®

Western blot analysis of ERLIN1 using anti-ERLIN1 antibody (A08034-3)

Immunoprecipitating ERLIN1 in A549 whole cell lysate

Human

IP, WB

$370
Cat # A08034-3
100 μg/vial

ERLIN1 Overview

Facts about Erlin-1.

ERLIN1 3D structure. Source: alphafold

Erlin-1 (ERLIN1)

Part of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.

Binds cholesterol and might promote ER retention of the SCAP-SREBF complicated (PubMed:24217618). .

Gene Information

Human
Gene Name:	ERLIN1
Uniprot:	O75477
Entrez:	10613

Family

Belongs to:

band 7/mec-2 family

Alternative Names

Band_7 23-211 Keo4 (Interim) similar to C.elegans protein C42C1.9; C10orf69; chromosome 10 open reading frame 69; Endoplasmic reticulum lipid raft-associated protein 1; ER lipid raft associated 1; Erlin-1; KE04SPFH domain-containing protein 1; KEO4; Protein KE04; SPFH domain family, member 1; SPFH1; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1

Molecular Weight

Mass (kDA):
39.171 kDA

Genomic Context


Human

Location:	10q24.31
Sequence:	10; NC_000010.11 (100150094..100186029, complement)

Tissue Specificity

Expressed in heart, placenta, liver, kidney, pancreas, prostate, testis, ovary and small intestine.

Subcellular Localizations

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Associated with lipid raft-like domains of the endoplasmic reticulum membrane.

Diseases

Ischemic Stroke
Myocardial Infarction
Hemorrhage
Subarachnoid Hemorrhage
Infarction
Cerebrovascular Accident
Brain Hemorrhage

Intracranial Hemorrhages
Cerebral Hemorrhage

Interacting Proteins

AGR3
ERLIN2
SEC22A
TMEM199

Pathways

Rna Interference

PTMs

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ERLIN1

References

PMID: 11118313 by Li N., et al. Identification and characterization of a novel gene KE04 differentially expressed by activated human dendritic cells.

PMID: 19240031 by Pearce M.M.P., et al. An endoplasmic reticulum (ER) membrane complex composed of SPFH1 and SPFH2 mediates the ER-associated degradation of inositol 1,4,5- trisphosphate receptors.