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- Table of Contents
Erlin-2 Antibodies
AND ERLIN2 ELISA kits, Erlin-2 Proteins
Many biological assays use antibodies to detect Erlin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Erlin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Erlin-2 antibodies...
Designing a Western blot for Erlin-2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ERLIN2 Western Blot GuideERLIN2 Infographic by Boster Bio
All ERLIN2 Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M07042-1
100 μg/vial
Cat # M07042-1
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A07042-2
100 μg/vial
Cat # A07042-2
100 μg/vial
ERLIN2 Overview
Facts about Erlin-2.
Erlin-2 (ERLIN2)
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 (PubMed:19240031, PubMed:17502376). Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex (PubMed:21343306).
Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complicated (PubMed:24217618).
Gene Information
| Human | |
|---|---|
| Gene Name: | ERLIN2 |
| Uniprot: | O94905 |
| Entrez: | 11160 |
Family
| Belongs to: |
|---|
| band 7/mec-2 family |
Alternative Names
C8orf2SPFH domain-containing protein 2; Endoplasmic reticulum lipid raft-associated protein 2; ER lipid raft associated 2; Erlin-2; MGC87072; NET32; SPFH domain family, member 2; SPFH2chromosome 8 open reading frame 2; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2
Molecular Weight
Mass (kDA):
37.84 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8p11.23 |
| Sequence: | 8; NC_000008.11 (37736627..37758422) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Associated with lipid raft-like domains of the endoplasmic reticulum membrane.
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Spastic Paraplegia, Hereditary
- Paraplegia
- Muscle Spasticity
- Cell Transformation, Neoplastic
- Spastic Paraplegia
- Neurodegenerative Disorders
- Weakness
- Motor Neuron Disease
- Mammary Neoplasms
- Nerve Degeneration
Interacting Proteins
- AMFR
- ERLIN1
- TMUB1
Pathways
- Rna Interference
- Cell Growth
- Localization
- Transport
- Cell Proliferation
- Cell Death
- Protein Maturation
- Lipid Storage
- Regulation Of Gene Expression
PTMs
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ERLIN2
bosterbio.com/bosterbio-gene-info-cards/ERLIN2
References
PMID: 10449903 by Ikegawa S., et al. Cloning and characterization of a novel gene (C8orf2), a human representative of a novel gene family with homology to C. elegans C42.C1.9.
PMID: 19240031 by Pearce M.M.P., et al. An endoplasmic reticulum (ER) membrane complex composed of SPFH1 and SPFH2 mediates the ER-associated degradation of inositol 1,4,5- trisphosphate receptors.