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Erlin-2 Antibodies
AND ERLIN2 ELISA kits, Erlin-2 Proteins
Many biological assays use antibodies to detect Erlin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Erlin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Erlin-2 antibodies...
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ERLIN2 Infographic by Boster Bio
All ERLIN2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A07042-2
100 μg/vial
Cat # A07042-2
100 μg/vial
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M07042-1
100 μg/vial
Cat # M07042-1
100 μg/vial
ERLIN2 Overview
Facts about Erlin-2.
Erlin-2 (ERLIN2)
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 (PubMed:19240031, PubMed:17502376). Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex (PubMed:21343306).
Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complicated (PubMed:24217618).
Gene Information
| Human | |
|---|---|
| Gene Name: | ERLIN2 |
| Uniprot: | O94905 |
| Entrez: | 11160 |
Family
| Belongs to: |
|---|
| band 7/mec-2 family |
Alternative Names
C8orf2SPFH domain-containing protein 2; Endoplasmic reticulum lipid raft-associated protein 2; ER lipid raft associated 2; Erlin-2; MGC87072; NET32; SPFH domain family, member 2; SPFH2chromosome 8 open reading frame 2; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2
Molecular Weight
Mass (kDA):
37.84 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8p11.23 |
| Sequence: | 8; NC_000008.11 (37736627..37758422) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Associated with lipid raft-like domains of the endoplasmic reticulum membrane.
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Spastic Paraplegia, Hereditary
- Paraplegia
- Muscle Spasticity
- Cell Transformation, Neoplastic
- Spastic Paraplegia
- Neurodegenerative Disorders
- Weakness
- Motor Neuron Disease
- Mammary Neoplasms
- Nerve Degeneration
Interacting Proteins
- AMFR
- ERLIN1
- TMUB1
Pathways
- Rna Interference
- Cell Growth
- Localization
- Transport
- Cell Proliferation
- Cell Death
- Protein Maturation
- Lipid Storage
- Regulation Of Gene Expression
PTMs
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ERLIN2
bosterbio.com/bosterbio-gene-info-cards/ERLIN2
References
PMID: 10449903 by Ikegawa S., et al. Cloning and characterization of a novel gene (C8orf2), a human representative of a novel gene family with homology to C. elegans C42.C1.9.
PMID: 19240031 by Pearce M.M.P., et al. An endoplasmic reticulum (ER) membrane complex composed of SPFH1 and SPFH2 mediates the ER-associated degradation of inositol 1,4,5- trisphosphate receptors.