ERN2 Antibodies

AND ERN2 ELISA kits, ERN2 Proteins

Many biological assays use antibodies to detect ERN2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ERN2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ERN2 antibodies...

We validate the specificity of these antibodies to ERN2 by testing them on tissues known to express ERN2 positively and negatively. Browse below to find the ERN2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for ERN2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the ERN2 Western Blot Guide

ERN2 Infographic by Boster Bio

All ERN2 Products

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Product

Figures

Specificity

Applications

Price

Anti-ERN2 Antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using ERN2 Antibody

Immunofluorescence analysis of A549 cells, using ERN2 Antibody

Human, Mouse

ELISA, IF, IHC, ICC

$335
Cat # A05659-1
100ul

Anti-ERN2 Antibody Picoband®

Western blot analysis of ERN2 using anti-ERN2 antibody (A05659-2)

Flow Cytometry analysis of Jurkat cells using anti-ERN2 antibody (A05659-2)

Human

ELISA, Flow Cytometry, WB

$370
Cat # A05659-2
100 μg/vial

IRE1 (ERN2) (NM_033266) Human Over-expression Lysate

Human

$960
Cat # LS010595
20 µg, 100 µg

ERN2 Overview

Facts about Serine/threonine-protein kinase/endoribonuclease IRE2.

ERN2 3D structure. Source: alphafold

Serine/threonine-protein kinase/endoribonuclease IRE2 (ERN2)

Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic.

Appears to play no part in the unfolded-protein reply, unlike closely related proteins. .

Gene Information

Human
Gene Name:	ERN2
Uniprot:	Q76MJ5
Entrez:	10595

Family

Belongs to:

protein kinase superfamily

Alternative Names

EC 2.7.11; endoplasmic reticulum to nucleus signaling 2; endoplasmic reticulum to nucleus signalling 2; Endoplasmic reticulum-to-nucleus signaling 2; ER to nucleus signalling 2; hIRE2p; inositol-requiring 1 beta; Inositol-requiring protein 2; IRE1, S. cerevisiae, homolog of; Ire1-beta; IRE1bIRE1 beta; IRE2; serine/threonine-protein kinase/endoribonuclease IRE2

Molecular Weight

Mass (kDA):
102.48 kDA

Genomic Context


Human

Location:	16p12.2
Sequence:	16; NC_000016.10 (23690310..23713248, complement)

Subcellular Localizations

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Diseases

Endoplasmic Reticulum Stress
Physiological Stress
Malignant Neoplasms
Neoplasms
Diabetes Mellitus
Alzheimer's Disease
Ischemia
Inflammation
Neurodegenerative Disorders
Hypoxia
Diabetes Mellitus, Non-insulin-dependent
Parkinson Disease

Obesity
Virus Diseases
Insulin Resistance
Tumor Angiogenesis
Hepatitis
Neuroblastoma
Atherosclerosis

Pathways

Cell Death
Translation
Protein Folding
Secretion
Pathogenesis
Secretory Pathway
Proteolysis
Autophagy
Cell Differentiation
Response To Endoplasmic Reticulum Stress
Response To Stress
Cell Cycle
Angiogenesis

Plasma Cell Differentiation
Programmed Cell Death
Mrna Splicing
Transport
Protein Secretion
Inflammatory Response
Induction Of Apoptosis

PTMs

Phosphorylation
Cleavage
Dephosphorylation

Ubiquitination
Glycosylation
Acetylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ERN2

References

PMID: 11175748 by Iwawaki T., et al. Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress.