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- Table of Contents
Facts about ERBB receptor feedback inhibitor 1.
Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4.
| Human | |
|---|---|
| Gene Name: | ERRFI1 |
| Uniprot: | Q9UJM3 |
| Entrez: | 54206 |

| Belongs to: |
|---|
| MIG6 family |

ERBB receptor feedback inhibitor 1; GENE-33; MIG6; MIG-6Mitogen-inducible gene 6 protein; RALTreceptor-associated late transducer
Mass (kDA):
50.56 kDA

| Human | |
|---|---|
| Location: | 1p36.23 |
| Sequence: | 1; NC_000001.11 (8011725..8026309, complement) |
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes (By similarity).





PMID: 7641805 by Wick M., et al. Identification of a novel mitogen-inducible gene (mig-6): regulation during G1 progression and differentiation.
PMID: 18046415 by Zhang X., et al. Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.