- Table of Content
Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes.
|XPG/RAD2 endonuclease family|
|Sequence:||1; NC_000001.11 (241847967..241889939)|
Highly expressed in bone marrow, testis and thymus. Expressed at lower levels in colon, lymph nodes, ovary, placenta, prostate, small intestine, spleen and stomach.
Nucleus. Colocalizes with PCNA to discrete nuclear foci in S-phase.