Exostosin-like 3 Antibodies

AND EXTL3 ELISA kits, Exostosin-like 3 Proteins

Many biological assays use antibodies to detect Exostosin-like 3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Exostosin-like 3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Exostosin-like 3 antibodies...

We validate the specificity of these antibodies to Exostosin-like 3 by testing them on tissues known to express EXTL3 positively and negatively. Browse below to find the EXTL3 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for Exostosin-like 3? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the EXTL3 IHC Guide

EXTL3 Infographic by Boster Bio

All EXTL3 Products

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Specificity

Applications

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Anti-Exostosin-like 3 EXTL3 Antibody

Western blot analysis of extracts of various cell lines, using EXTL3 antibody at 1:1000 dilution

Immunohistochemistry of paraffin-embedded rat kidney using EXTL3 Rabbit pAb at dilution of 1:100

Immunohistochemistry of paraffin-embedded mouse kidney using EXTL3 Rabbit pAb at dilution of 1:100

Human, Mouse, Rat

IHC, WB

$405
Cat # A07636
100ul

EXTL3 (NM_001440) Human Over-expression Lysate

Human

$628
Cat # LS002137
20 µg, 100 µg

EXTL3 Overview

Facts about Exostosin-like 3.

EXTL3 3D structure. Source: alphafold

Exostosin-like 3 (EXTL3)

Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS). Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs) (PubMed:28132690, PubMed:28148688).

Required for the function of REG3A in regulating keratinocyte proliferation and differentiation (PubMed:22727489). .

Gene Information

Human
Gene Name:	EXTL3
Uniprot:	O43909
Entrez:	2137

Family

Belongs to:

glycosyltransferase 47 family

Alternative Names

botv; DKFZp686C2342; EC 2.4.1.223; exostoses (multiple)-like 3; Exostosin like 3; Exostosin-like 3; EXTL1L; EXTL3; EXTR1BOTV; EXT-related protein 1; Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; Hereditary multiple exostoses gene isolog; KIAA0519; Multiple exostosis-like protein 3; Putative tumor suppressor protein EXTL3; reg receptor; REG; REGR; RPR

Molecular Weight

Mass (kDA):
104.749 kDA

Genomic Context


Human

Location:	8p21.1
Sequence:	8; NC_000008.11 (28607736..28755599)

Tissue Specificity

Ubiquitous. Expressed in keratinocytes.

Subcellular Localizations

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus.

Diseases

Hereditary Multiple Exostoses
Exostoses
Neoplasms
Malignant Neoplasms
Carcinoma
Malignant Neoplasm Of Breast
Colorectal Cancer
Bone Diseases
Hereditary Diseases
Colorectal Neoplasms
Alzheimer's Disease
Neoplasm Metastasis
Skin Injury

Metastatic Malignant Neoplasm To The Lymph Node
Colonic Neoplasms
Malignant Tumor Of Colon
Bone Neoplasms
Eye Abnormalities
Carcinogenesis
Mucopolysaccharidoses

Pathways

Cell Proliferation
Gastrulation
Gene Silencing
Insulin Secretion
Aging
Brain Development
Cartilage Morphogenesis
Limb Development
Methylation
Neuroprotection

Keratinocyte Proliferation
Embryonic Morphogenesis
Rna Interference
Secretion

PTMs

Demethylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EXTL3

References

PMID: 9479495 by van Hul W., et al. Identification of a third EXT-like gene (EXTL3) belonging to the EXT gene family.

PMID: 9473480 by Saito T., et al. Structure, chromosomal location, and expression profile of EXTR1 and EXTR2, new members of the multiple exostoses gene family.