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- Table of Contents
1 Citations 7 Q&As
4 Citations 7 Q&As
Facts about Neutrophil elastase.
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Human | |
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Gene Name: | ELANE |
Uniprot: | P08246 |
Entrez: | 1991 |
Belongs to: |
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peptidase S1 family |
Bone marrow serine protease; EC 3.4.21; EC 3.4.21.37; ELA2; ELA2granulocyte-derived elastase; ELANE; elastase 2, neutrophil; elastase, neutrophil expressed; Elastase-2; GE; HLEelastase-2; HNE; Human leukocyte elastase; Leukocyte Elastase; Medullasin; NE; Neutrophil Elastase; PMN elastase; PMN-E; polymorphonuclear elastase; SCN1
Mass (kDA):
28.518 kDA
Human | |
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Location: | 19p13.3 |
Sequence: | 19; NC_000019.10 (850997..856250) |
Bone marrow cells.
Cytoplasmic vesicle, phagosome. Localized in phagolysosomes following ingestion of E.coli by neutrophils.
If you're looking for an anti-neutrophil, high-quality, Anti-Neutrophil Elasta Antibody you've likely come across Boster Bio. This article will provide you with crucial information about the product. We will also look at Steven Boster's company as well as the ELANE marker, as well as its many uses. Let's get started!
An important instrument for studying inflammation and other conditions that cause inflammation is a reagent that can detect Neutrophil Elastase/ELANES. Boster Bio's Anti Neutrophil Elastase/ELANE antibody offers high affinity against this protein. The company offers multiple antibodies to this end and has a broad selection. Each kit has been tested against more than 250 different tissues and has been validated for ELISA and WB. The antibodies are also assessed quantitatively against known amounts of recombinant proteins in the presence of reagents, controls, and un-transfected cells.
Created by Boster Bio, this rabbit polyclonal antibody recognizes Neutrophil elastase (NEE). The antibody reacts with Rat and Mouse Neutrophils. Boster Bio's Anti-Neutrophil Elastase/ELANE Antibody Picoband has been validated for ELISA, immunohistochemistry, and Western Blot.
Neutrophil elastase (NELA) is a serine protease present in the cytoplasm of human lymphocytes. It plays a significant role in the innate immune defense. In addition to the ELASTASE activity the enzyme also has secretagogue properties and participates in the process of tissue remodeling. A set of related genes encode Elastases, which belong to the serine proteases family. These genes encode a protein called a preproprotein. This is then processed into an active protease. The enzyme elastase hydrolyzes proteins within specialized neutrophil Lysosomes.
Applications of the ELANE marker are vital to many research studies. Biological assays make use of antibodies to detect Neutrophil Elastase in a variety of samples, which includes rats or mice. Boster Bio uses rabbit and mouse as model organisms to create antibodies against Neutrophil Ellastase. These antibodies can be utilized by researchers from all over the world to test how the proteins are expressed within the body.
PMID: 3479752 by Nakamura H., et al. Nucleotide sequence of human bone marrow serine protease (medullasin) gene.
PMID: 2902087 by Takahashi H., et al. Structure of the human neutrophil elastase gene.
*More publications can be found for each product on its corresponding product page