Coagulation factor XII Antibodies

AND F12 ELISA kits, Coagulation factor XII Proteins

Many biological assays use antibodies to detect Coagulation factor XII, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Coagulation factor XII in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Coagulation factor XII antibodies...

We validate the specificity of these antibodies to Coagulation factor XII by testing them on tissues known to express F12 positively and negatively. Browse below to find the F12 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for Coagulation factor XII? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the F12 Western Blot Guide

F12 Infographic by Boster Bio

All F12 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-F12 / Factor XII Reference Antibody (garadacimab)

The purity of Anti-F12/Factor XII Reference Antibody (garadacimab)is more than 100%

Human, Mouse

ELISA, Flow Cytometry, Functional Assay, Kinetics

$486
Cat # M01226-2
100 μg

Anti-Factor XII/F12 Antibody Picoband®

Western blot analysis of Factor XII/F12 using anti-Factor XII/F12 antibody (A01226-4)

Human, Mouse, Rat

ELISA, WB

$370
Cat # A01226-4
100 μg/vial

F12 Overview

Facts about Coagulation factor XII.

F12 3D structure. Source: alphafold

Coagulation factor XII (F12)

Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the creation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII initially to alpha-factor XIIa and then trypsin cleaves it to beta- factor XIIa.

Alpha-factor XIIa activates factor XI to factor XIa. .

Gene Information

Human
Gene Name:	F12
Uniprot:	P00748
Entrez:	2161

Family

Belongs to:

peptidase S1 family

Alternative Names

beta-factor XIIa part 1; coagulation factor XII (Hageman factor); coagulation factor XII; coagulation factor XIIa heavy chain; coagulation factor XIIa light chain; EC 3.4.21; EC 3.4.21.38; HAE3; HAEX; HAFbeta-factor XIIa part 2; Hageman factor

Molecular Weight

Mass (kDA):
67.792 kDA

Genomic Context


Human

Location:	5q35.3
Sequence:	5; NC_000005.10 (177402138..177409564, complement)

Subcellular Localizations

Secreted.

Diseases

Neoplasms
Malignant Neoplasms
Cholera
Tissue Adhesions
Carcinoma
Pituitary Diseases
Adenocarcinoma
Thrombosis
Cell Transformation, Neoplastic
Immunologic Deficiency Syndromes
Hyperplasia
Diabetes Mellitus
Nervousness

Mammary Neoplasms
Malignant Paraganglionic Neoplasm
Leukemia
Melanoma
Angioedema
Angioedemas, Hereditary
Corneal Diseases

Interacting Proteins

C1QBP

Pathways

Cell Growth
Cell Proliferation
Secretion
Coagulation
Regeneration
Cell Cycle
Cell Death
Cell Differentiation
Transport
Pathogenesis
Localization
Wound Healing
Cell Adhesion

Spermatogenesis
Cell Division
Cell Migration
Embryo Development
Reverse Transcription
Contact Inhibition
Fermentation

PTMs

Cleavage
Phosphorylation
Oxidation
Reduction
Hydroxylation
Glycosylation

Demethylation
Ribosylation
Biotinylation
Nitration
Deacetylation
Methylation

Deglycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/F12

References

PMID: 2888762 by Cool D.E., et al. Characterization of the human blood coagulation factor XII gene. Intron/exon gene organization and analysis of the 5'-flanking region.

PMID: 3754331 by Tripodi M., et al. cDNA sequence coding for human coagulation factor XII (Hageman).