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- Table of Contents
Coagulation factor XII Antibodies
AND F12 ELISA kits, Coagulation factor XII Proteins
Many biological assays use antibodies to detect Coagulation factor XII, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Coagulation factor XII in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Coagulation factor XII antibodies...
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F12 Infographic by Boster Bio
All F12 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, WB
$399
Cat # A01226
100μl
Cat # A01226
100μl
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A01226-3
100ul
Cat # A01226-3
100ul
Human
WB
$523
Cat # M01226-1
100 µl
Cat # M01226-1
100 µl
Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01226-2
100 μg
Cat # M01226-2
100 μg
F12 Overview
Facts about Coagulation factor XII.
Coagulation factor XII (F12)
Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the creation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII initially to alpha-factor XIIa and then trypsin cleaves it to beta- factor XIIa.
Alpha-factor XIIa activates factor XI to factor XIa. .
Gene Information
| Human | |
|---|---|
| Gene Name: | F12 |
| Uniprot: | P00748 |
| Entrez: | 2161 |
Family
| Belongs to: |
|---|
| peptidase S1 family |
Alternative Names
beta-factor XIIa part 1; coagulation factor XII (Hageman factor); coagulation factor XII; coagulation factor XIIa heavy chain; coagulation factor XIIa light chain; EC 3.4.21; EC 3.4.21.38; HAE3; HAEX; HAFbeta-factor XIIa part 2; Hageman factor
Molecular Weight
Mass (kDA):
67.792 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q35.3 |
| Sequence: | 5; NC_000005.10 (177402138..177409564, complement) |
Subcellular Localizations
Secreted.
Diseases
- Neoplasms
- Malignant Neoplasms
- Cholera
- Tissue Adhesions
- Carcinoma
- Pituitary Diseases
- Adenocarcinoma
- Thrombosis
- Cell Transformation, Neoplastic
- Immunologic Deficiency Syndromes
- Hyperplasia
- Diabetes Mellitus
- Nervousness
Interacting Proteins
- C1QBP
Pathways
- Cell Growth
- Cell Proliferation
- Secretion
- Coagulation
- Regeneration
- Cell Cycle
- Cell Death
- Cell Differentiation
- Transport
- Pathogenesis
- Localization
- Wound Healing
- Cell Adhesion
PTMs
- Cleavage
- Phosphorylation
- Oxidation
- Reduction
- Hydroxylation
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/F12
bosterbio.com/bosterbio-gene-info-cards/F12
References
PMID: 2888762 by Cool D.E., et al. Characterization of the human blood coagulation factor XII gene. Intron/exon gene organization and analysis of the 5'-flanking region.
PMID: 3754331 by Tripodi M., et al. cDNA sequence coding for human coagulation factor XII (Hageman).