Coagulation factor VII (F7)

Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form.

Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis.