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- Table of Contents
Acyl-CoA (8-3)-desaturase Antibodies
AND FADS1 ELISA kits, Acyl-CoA (8-3)-desaturase Proteins
Many biological assays use antibodies to detect Acyl-CoA (8-3)-desaturase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Acyl-CoA (8-3)-desaturase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Acyl-CoA (8-3)-desaturase antibodies...
Designing an IHC experiment for Acyl-CoA (8-3)-desaturase? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the FADS1 IHC GuideFADS1 Infographic by Boster Bio
All FADS1 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, IHC, WB
$370
Cat # A02535-1
100 μg/vial
Cat # A02535-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M02535
100 μl/vial
Cat # M02535
100 μl/vial
FADS1 Overview
Facts about Acyl-CoA (8-3)-desaturase.
Acyl-CoA (8-3)-desaturase (FADS1)
Isoform 2 doesn't exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity (By similarity). Isoform 1 is a component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3).
Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20:3n-6) and eicosatetraenoic acid (20:4n-3) to generate arachidonic acid (AA) (20:4n-6) and eicosapentaenoic acid (EPA)(20:5n-3), respectively. .
Gene Information
| Human | |
|---|---|
| Gene Name: | FADS1 |
| Uniprot: | O60427 |
| Entrez: | 3992 |
Family
| Belongs to: |
|---|
| fatty acid desaturase type 1 family |
Alternative Names
D5DFLJ90273; Delta(5) desaturase; Delta(5) fatty acid desaturase; Delta-5 desaturase; delta-5 fatty acid desaturase; EC 1.14.19; EC 1.14.19.-; FADS6; FADSD5LLCDL1; fatty acid desaturase 1; FLJ38956; linoleoyl-CoA desaturase (delta-6-desaturase)-like 1; TU12
Molecular Weight
Mass (kDA):
51.964 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q12.2 |
| Sequence: | 11; NC_000011.10 (61799627..61817003, complement) |
Tissue Specificity
Widely expressed, with highest levels in liver, brain, adrenal gland and heart. Highly expressed in fetal liver and brain.
Subcellular Localizations
[Isoform 1]: Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion.; [Isoform 2]: Endoplasmic reticulum membrane; Multi-pass membrane protein.
Diseases
- Diabetes Mellitus
- Inflammation
- Obesity
- Diabetes Mellitus, Non-insulin-dependent
- Cardiovascular Diseases
- Malignant Neoplasms
- Insulin Resistance
- Dyslipidemias
- Dysequilibrium Syndrome
- Coronary Artery Disease
- Hyperglycemia
- Insulin Sensitivity
- Hypertensive Disease
Pathways
- Glucose Homeostasis
- Lactation
- Pathogenesis
- Secretion
- Insulin Secretion
- Localization
- Inflammatory Response
- Cognition
- Cell Proliferation
- Methylation
- Transport
- Fatty Acid Elongation
- Fertilization
PTMs
Research Areas
- Diabetes Research
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FADS1
bosterbio.com/bosterbio-gene-info-cards/FADS1
References
PMID: 10601301 by Cho H.P., et al. Cloning, expression, and fatty acid regulation of the human Delta-5 desaturase.
PMID: 10769175 by Leonard A.E., et al. cDNA cloning and characterization of human Delta5-desaturase involved in the biosynthesis of arachidonic acid.