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- Table of Contents
Facts about Constitutive coactivator of PPAR-gamma-like protein 1.
Activates src family kinases and functions as a scaffolding protein allowing src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II.
| Human | |
|---|---|
| Gene Name: | FAM120A |
| Uniprot: | Q9NZB2 |
| Entrez: | 23196 |

| Belongs to: |
|---|
| constitutive coactivator of PPAR-gamma family |

C9orf10MGC133257; chromosome 9 open reading frame 10; constitutive coactivator of PPAR-gamma-like protein 1; DNA polymerase-transactivated protein 1; DNA polymerase-transactivated protein 5; DNAPTP1; DNAPTP5; family with sequence similarity 120A; KIAA0183MGC111527; OSSA; Oxidative stress-associated Src activator; Protein FAM120A
Mass (kDA):
121.888 kDA

| Human | |
|---|---|
| Location: | 9q22.31 |
| Sequence: | 9; NC_000009.12 (93451685..93566112) |
Ubiquitously expressed. Highly expressed in scirrhous-type gastric cancer tissues compared with normal gastric mucosa (at protein level).
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Translocates to plasma membrane upon ultraviolet exposure.


PMID: 14585507 by Holden S., et al. The human gene CXorf17 encodes a member of a novel family of putative transmembrane proteins: cDNA cloning and characterization of CXorf17 and its mouse ortholog orf34.
PMID: 19015244 by Tanaka M., et al. A novel RNA-binding protein, Ossa/C9orf10, regulates activity of Src kinases to protect cells from oxidative stress-induced apoptosis.