Fanconi anemia group M protein (FANCM)

DNA-dependent ATPase part of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, resulting in monoubiquitination of the FANCI-FANCD2 complicated in response to DNA damage, cellular resistance to DNA cross-linking medications, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429).

In complicated with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures like a movable replication fork.