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- Table of Contents
FCGRT Antibodies
AND FCGRT ELISA kits, FCGRT Proteins
Many biological assays use antibodies to detect FCGRT, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FCGRT in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FCGRT antibodies...
Designing a Western blot for FCGRT? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the FCGRT Western Blot GuideFCGRT Infographic by Boster Bio
All FCGRT Products
Product
Figures
Specificity
Applications
Price
Mouse
ELISA
$750
Cat # EK1454
96 wells/kit, with removable strips.
Cat # EK1454
96 wells/kit, with removable strips.
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M09198-3
100 μg
Cat # M09198-3
100 μg
Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M09198-2
100 μg
Cat # M09198-2
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M09198-1
100 μg
Cat # M09198-1
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M09198
100 μg
Cat # M09198
100 μg
SDS-PAGE, Bioactivity
$300
Cat # PROTP55899-1
Starting from 10ug
Cat # PROTP55899-1
Starting from 10ug
FCGRT Overview
Facts about IgG receptor FcRn large subunit p51.
IgG receptor FcRn large subunit p51 (FCGRT)
Binds to the Fc region of monomeric immunoglobulins gamma (PubMed:7964511, PubMed:10933786). Mediates the selective uptake of IgG from milk and assists newborn animals to acquire passive immunity.
IgG in the milk is bound at the apical surface of the intestinal epithelium. The consequent FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is discharged from FcRn into blood or tissue fluids (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | FCGRT |
| Uniprot: | P55899 |
| Entrez: | 2217 |
Family
| Belongs to: |
|---|
| immunoglobulin superfamily |
Alternative Names
alpha-chain; Fc fragment of IgG, receptor, transporter, alpha; FCGRT; FcRn alpha chain; FCRN; FCRNimmunoglobulin receptor, intestinal, heavy chain; IgG Fc fragment receptor transporter alpha chain; IgG receptor FcRn large subunit p51; major histocompatibility complex class I-like Fc receptor; Neonatal Fc receptor; neonatal Fc-receptor for Ig
Molecular Weight
Mass (kDA):
39.743 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.33 |
| Sequence: | 19; NC_000019.10 (49512661..49526428) |
Tissue Specificity
Expressed in full-term placenta, heart, lung, liver, muscle, kidney, pancreas, and both fetal and adult small intestine.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Endosome membrane.
Diseases
- Variable Number Tandem Repeat
- Autoimmune Reaction
- Dysequilibrium Syndrome
- Common Variable Immunodeficiency
- Tetanus
- Neurofibromatosis 1
- Lupus Nephritis
- Autoimmune Diseases
- Glaucoma
- Blind Vision
Pathways
- Transport
- Cytokine Production
- Dna Amplification
- Cell Death
- Localization
PTMs
- Disulfide bond
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FCGRT
bosterbio.com/bosterbio-gene-info-cards/FCGRT
References
PMID: 7964511 by Story C.M., et al. A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus.
PMID: 10998088 by Mikulska J.E., et al. Cloning and analysis of the gene encoding the human neonatal Fc receptor.