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FDPS Antibodies
AND FDPS ELISA kits, FDPS Proteins
Many biological assays use antibodies to detect FDPS, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FDPS in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FDPS antibodies...
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FDPS Infographic by Boster Bio
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FDPS Overview
Facts about Farnesyl pyrophosphate synthase.
Farnesyl pyrophosphate synthase (FDPS)
Key enzyme in isoprenoid biosynthesis that catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation.
Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the consequent geranylpyrophosphate to the best product farnesyl pyrophosphate. .
Gene Information
| Human | |
|---|---|
| Gene Name: | FDPS |
| Uniprot: | P14324 |
| Entrez: | 2224 |
Family
| Belongs to: |
|---|
| FPP/GGPP synthase family |
Alternative Names
6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; EC 2.5.1.1; EC 2.5.1.10; farnesyl diphosphate synthaseFPP synthetase; farnesyl pyrophosphate synthase; farnesyl pyrophosphate synthetase, dimethylallyltranstransferase; FPP synthase; FPPS; FPSgeranyltranstransferase; Geranyltranstransferase; KIAA1293
Molecular Weight
Mass (kDA):
48.275 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q22 |
| Sequence: | 1; NC_000001.11 (155308748..155320666) |
Subcellular Localizations
Cytoplasm.
Diseases
- Malignant Neoplasms
- Osteoporosis
- Cholangiocarcinoma
- Neoplasms
- Osteoporosis, Postmenopausal
- Alzheimer's Disease
- Carcinoma
- Fibrosis
- Hyperinsulinism
- Diabetes Mellitus
- Diabetes Mellitus, Non-insulin-dependent
- Decreased Immunologic Activity [pe]
- Inflammation
Pathways
- Transport
- Cell Proliferation
- Immune Response
- Translation
- Cholesterol Efflux
- Localization
- Methylation
- Bone Resorption
- Cholesterol Homeostasis
- Secretion
- Response To Paclitaxel
- Nuclear Export
- Cell Cycle
PTMs
- Prenylation
- Farnesylation
Research Areas
- Core ESC-Like Genes
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FDPS
bosterbio.com/bosterbio-gene-info-cards/FDPS
References
PMID: 2690933 by Sheares B.T., et al. Cloning, analysis, and bacterial expression of human farnesyl pyrophosphate synthetase and its regulation in Hep G2 cells.
PMID: 11773414 by Lefebvre L., et al. Oncoviral bovine leukemia virus G4 and human T-cell leukemia virus type 1 p13(II) accessory proteins interact with farnesyl pyrophosphate synthetase.