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- Table of Contents
FDX1 Antibodies
AND FDX1 ELISA kits, FDX1 Proteins
Many biological assays use antibodies to detect FDX1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FDX1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FDX1 antibodies...
Designing a Western blot for FDX1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the FDX1 Western Blot GuideDesigning an IHC experiment for FDX1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the FDX1 IHC GuideFDX1 Infographic by Boster Bio
All FDX1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M05441
100 μl/vial
Cat # M05441
100 μl/vial
FDX1 Overview
Facts about Adrenodoxin, mitochondrial.
Adrenodoxin, mitochondrial (FDX1)
Essential for the synthesis of various steroid hormones (PubMed:20547883, PubMed:21636783). Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis (PubMed:20547883, PubMed:21636783).
Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage (PubMed:20547883, PubMed:21636783). Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | FDX1 |
| Uniprot: | P10109 |
| Entrez: | 2230 |
Family
| Belongs to: |
|---|
| adrenodoxin/putidaredoxin family |
Alternative Names
Adrenal ferredoxin; adrenodoxin, mitochondrial; ADXhepatoredoxin; FDX; ferredoxin 1; ferredoxin-1; Hepatoredoxin; LOH11CR1D; mitochondrial adrenodoxin
Molecular Weight
Mass (kDA):
19.393 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q22.3 |
| Sequence: | 11; NC_000011.10 (110429948..110464884) |
Tissue Specificity
Highest levels in the adrenal gland (at protein level). Also detected in kidney and testis (at protein level).
Subcellular Localizations
Mitochondrion matrix.
Diseases
- Melanoma
- Neoplasms
- Cell Invasion
- Adrenal Hyperplasia
- Iron Overload
- Ataxia
- Malignant Paraganglionic Neoplasm
- Ambiguous Genitalia
- Malignant Neoplasm Of Liver
- Hypertensive Disease
- Ataxia Telangiectasia
- Malignant Neoplasms
- Telangiectasis
Pathways
- Transport
- Protein Phosphorylation
- Mitochondrial Translocation
- Cell Death
- Protein Targeting
- Fertilization
- Virulence
- Pathogenesis
PTMs
- Reduction
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FDX1
bosterbio.com/bosterbio-gene-info-cards/FDX1
References
PMID: 3229285 by Chang C.-Y., et al. Cloning and structure of the human adrenodoxin gene.
PMID: 3343244 by Picado-Leonard J., et al. Human adrenodoxin: cloning of three cDNAs and cycloheximide enhancement in JEG-3 cells.