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- Table of Contents
Filamin-B Antibodies
AND FLNB ELISA kits, Filamin-B Proteins
Many biological assays use antibodies to detect Filamin-B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Filamin-B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Filamin-B antibodies...
Designing a Western blot for Filamin-B? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the FLNB Western Blot GuideFLNB Infographic by Boster Bio
All FLNB Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02562-1
100 μg/vial
Cat # A02562-1
100 μg/vial
Human
IF, IHC, ICC, WB
$370
Cat # M02562-1
100 μg/vial
Cat # M02562-1
100 μg/vial
FLNB Overview
Facts about Filamin-B.
Filamin-B (FLNB)
Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins.
Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate.
Gene Information
| Human | |
|---|---|
| Gene Name: | FLNB |
| Uniprot: | O75369 |
| Entrez: | 2317 |
Family
| Belongs to: |
|---|
| filamin family |
Alternative Names
ABP-278filamin B, beta (actin binding protein 278); ABP-280 homolog; actin binding protein 278; Actin-binding-like protein; AOI; beta-filamin; DKFZp686O033; FH1; filamin B, beta; Filamin homolog 1; filamin-3; filamin-B; FLN1L; FLN3; FLN-B; Larsen syndrome 1 (autosomal dominant); LRS1; SCT; TABPABP-280; TAPDKFZp686A1668; Thyroid autoantigen; Truncated ABP; Truncated actin-binding protein
Molecular Weight
Mass (kDA):
278.164 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p14.3 |
| Sequence: | 3; NC_000003.12 (58008422..58172251) |
Tissue Specificity
Ubiquitous. Isoform 1 and isoform 2 are expressed in placenta, bone marrow, brain, umbilical vein endothelial cells (HUVEC), retina and skeletal muscle. Isoform 1 is predominantly expressed in prostate, uterus, liver, thyroid, stomach, lymph node, small intestine, spleen, skeletal muscle, kidney, placenta, pancreas, heart, lung, platelets, endothelial cells, megakaryocytic and erythroleukemic cell lines. Isoform 2 is predominantly expressed in spinal cord, platelet and Daudi cells. Also expressed in thyroid adenoma, neurofibrillary tangles (NFT), senile plaques in the hippocampus and cerebral cortex in Alzheimer disease (AD). Isoform 3 and isoform 6 are expressed predominantly in lung, heart, skeletal muscle, testis, spleen, thymus and leukocytes. Isoform 4 and isoform 5 are expressed in heart.
Subcellular Localizations
[Isoform 1]: Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Cytoplasm, myofibril, sarcomere, Z line. In differentiating myotubes, isoform 1, isoform 2 and isoform 3 are localized diffusely throughout the cytoplasm with regions of enrichment at the longitudinal actin stress fiber. In differentiated tubes, isoform 1 is also detected within the Z-lines.; [Isoform 2]: Cytoplasm, cytoskeleton, stress fiber.; [Isoform 3]: Cytoplasm, cytoskeleton, stress fiber.; [Isoform 6]: Cytoplasm, cytoskeleton. Polarized at the periphery of myotubes.
Diseases
- Dysplasia
- Congenital Abnormal Synostosis
- Atelosteogenesis
- Osteochondrodysplasias
- Larsen Syndrome
- Spondylocarpotarsal Synostosis Syndrome
- Mucopolysaccharidosis Iv
- Dwarfism
- Hypoplasia
- Boomerang Dysplasia
- Scoliosis, Unspecified
- Cleft Palate
- Dislocations
Interacting Proteins
- FLNA
- GRB2
- ISG15
- MAP3K1
- MAP3K4
- NCK1
- RAC1
Pathways
- Segmentation
- Ossification
- Endothelial Cell Migration
- Cell Migration
- Endochondral Ossification
- System Development
- Cell Motility
- Angiogenesis
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FLNB
bosterbio.com/bosterbio-gene-info-cards/FLNB
References
PMID: 9651345 by Takafuta T., et al. Human beta-filamin is a new protein that interacts with the cytoplasmic tail of glycoprotein Ibalpha.
PMID: 9694715 by Xu W.-F., et al. A novel human actin-binding protein homologue that binds to platelet glycoprotein Ibalpha.