Galactoside 2-alpha-L-fucosyltransferase 2 (FUT2)

Mediates the transfer of fucose into the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids (PubMed:7876235). The subsequent epitope plays a role in cell-cell interaction including host-microbe interaction (PubMed:12692541, PubMed:8018146).

Mediates interaction with intestinal microbiota influencing its composition (PubMed:21625510, PubMed:24733310, PubMed:22068912). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an important substrate for the last step in the soluble ABO blood group antigen synthesis pathway (PubMed:7876235).