FYN-binding protein 1 Antibodies

AND FYB1 ELISA kits, FYN-binding protein 1 Proteins

Many biological assays use antibodies to detect FYN-binding protein 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FYN-binding protein 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FYN-binding protein 1 antibodies...

We validate the specificity of these antibodies to FYN-binding protein 1 by testing them on tissues known to express FYB1 positively and negatively. Browse below to find the FYB1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FYB1 Infographic by Boster Bio

All FYB1 Products

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Product

Figures

Specificity

Applications

Price

Anti-FYB FYB1 Antibody

Western blot analysis of FYB on U937 cell lysate

Human

Flow Cytometry, IHC, WB

$405
Cat # A32410-1
100ul

Anti-FYB Rabbit Monoclonal Antibody

Western blot analysis of FYB using anti-FYB antibody (M32410-1)

Human, Mouse

IF, IHC, ICC, WB

$370
Cat # M32410-1
100 μl/vial

FYB1 (NM_001465) Human Over-expression Lysate

Human

$960
Cat # LS002533
20 µg, 100 µg

FYB1 Overview

Facts about FYN-binding protein 1.

FYB1 3D structure. Source: alphafold

FYN-binding protein 1 (FYB1)

Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells.
Modulates the expression of interleukin-2 (IL-2).

Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2.

Gene Information

Human
Gene Name:	FYB1
Uniprot:	O15117
Entrez:	2533

Family

Belongs to:

No superfamily

Alternative Names

ADAP; Adhesion and degranulation promoting adaptor protein; adhesion and degranulation-promoting adaptor protein; FYB; FYB-120/130SLAP-130FYN-binding protein (FYB-120/130); FYN binding protein; FYN-binding protein; FYN-T-binding protein; p120/p130; PRO0823; SLAP130; SLP-76-associated phosphoprotein

Molecular Weight

Mass (kDA):
85.387 kDA

Genomic Context


Human

Location:	5p13.1
Sequence:	5; NC_000005.10 (39105252..39274500, complement)

Tissue Specificity

Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues.

Subcellular Localizations

Cytoplasm. Nucleus. Cell junction. Colocalizes with TMEM47 at cell-cell contacts in podocytes.

Diseases

Tissue Adhesions
Malaria
Hemolytic Disorder
Erythroblastosis, Fetal
Cell Invasion
Yersinia Infections
Blood Group Incompatibility
Anemia
Inflammation
Malaria, Vivax
Hemorrhage
Hemolysis (disorder)
Transfusion Reaction

Anemia, Hemolytic
Wiskott-aldrich Syndrome
Chimera Disorder
Cholangiocarcinoma
Yersinia Pseudotuberculosis Infections
Malignant Neoplasms
Neoplasms

Interacting Proteins

FYN
LCP2
NCK1
NCK2
SKAP1

Pathways

Cell Activation
T Cell Activation
Cell Adhesion
Integrin Activation
Cytokine Production
Cell Proliferation
Localization
Virulence
Secretion
Phagocytosis
T Cell Proliferation
Cell Migration
Platelet Activation

Pathogenesis
Immune Response
Lipid Binding
T Cell Migration
T Cell Cytokine Production
Lymphocyte Activation
Proteolysis

PTMs

Phosphorylation
Dephosphorylation
Oxidation

Cleavage
Acylation
Deglycosylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FYB1

References

PMID: 9207119 by da Silva A.J., et al. Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain- containing leukocyte protein 76 and modulates interleukin 2 production.

PMID: 9115214 by Musci M.A., et al. Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases.