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- Table of Contents
FGFR4 Antibodies
AND FGFR4 ELISA kits, FGFR4 Proteins
Many biological assays use antibodies to detect FGFR4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FGFR4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FGFR4 antibodies...
Designing a Western blot for FGFR4? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the FGFR4 Western Blot GuideFGFR4 Infographic by Boster Bio
All FGFR4 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00769-3
100 μg
Cat # M00769-3
100 μg
Human, Mouse, Rat
ELISA
$540
Cat # EKC2516
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2516
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2515
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2515
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2514
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2514
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2513
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2513
1 kit, containing two 96-well plates and all necessary reagents
FGFR4 Overview
Facts about Fibroblast growth factor receptor 4.
Fibroblast growth factor receptor 4 (FGFR4)
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19.
Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades.
Gene Information
| Human | |
|---|---|
| Gene Name: | FGFR4 |
| Uniprot: | P22455 |
| Entrez: | 2264 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
CD334 antigen; CD334; EC 2.7.10; EC 2.7.10.1; FGF R4; FGFR4; FGFR-4; fibroblast growth factor receptor 4; JTK2hydroxyaryl-protein kinase; MGC20292; protein-tyrosine kinase; TKF; tyrosine kinase related to fibroblast growth factor receptor; tyrosylprotein kinase
Molecular Weight
Mass (kDA):
87.954 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q35.2 |
| Sequence: | 5; NC_000005.10 (177086915..177098144) |
Tissue Specificity
Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Endosome. Endoplasmic reticulum. Internalized from the cell membrane to recycling endosomes, and from there back to the cell membrane.; [Isoform 2]: Secreted.; [Isoform 3]: Cytoplasm.
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Malignant Neoplasm Of Breast
- Cell Transformation, Neoplastic
- Mammary Neoplasms
- Neoplasm Metastasis
- Liver Carcinoma
- Malignant Neoplasm Of Prostate
- Pituitary Diseases
- Malignant Paraganglionic Neoplasm
- Tumor Angiogenesis
Interacting Proteins
- MMP14
Pathways
- Cell Proliferation
- Localization
- Cell Growth
- Pathogenesis
- Regeneration
- Angiogenesis
- Translation
- Cell Motility
- Transport
- Cell Cycle
- Cell Differentiation
- Neurogenesis
- Cell Adhesion
PTMs
- Phosphorylation
- Glycosylation
- Methylation
- Reduction
- Farnesylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FGFR4
bosterbio.com/bosterbio-gene-info-cards/FGFR4
References
PMID: 1709094 by Partanen J.M., et al. FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern.
PMID: 7680645 by Ron D., et al. Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor.