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May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron advice via its interaction with UNC5D, and possibly also other UNC-5 household members.
|Sequence:||14; NC_000014.9 (85527372..85654428)|
Expressed in pancreas, skeletal muscle, brain, and heart.
Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane. Cell junction, focal adhesion. Secreted, extracellular space, extracellular matrix. Microsome membrane. Secreted. Cell junction, synapse, synaptosome. Proteolytic cleavage gives rise to a shedded ectodomain.