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Forkhead box protein P3 Antibodies
AND Foxp3 ELISA kits, Forkhead box protein P3 Proteins
Many biological assays use antibodies to detect Forkhead box protein P3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Forkhead box protein P3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Forkhead box protein P3 antibodies...
Designing a Western blot for Forkhead box protein P3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the FOXP3 Western Blot GuideFoxp3 Infographic by Boster Bio
All Foxp3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IF, IHC-P, WB
$481
Cat # A00011
0.1 mg
Cat # A00011
0.1 mg
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00011-5
20μL, 40μL, 100μL, 200μL
Cat # M00011-5
20μL, 40μL, 100μL, 200μL
Functional Assay
$2072
Cat # RC1044
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO.
Cat # RC1044
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO.
Foxp3 Overview
Facts about Forkhead box protein P3.
Forkhead box protein P3 (Foxp3)
Transcriptional regulator which is crucial for the development and inhibitory role of regulatory T-cells (Treg). Plays an important role in maintaining homeostasis of the immune system by permitting the acquisition of full suppressive function and stability of the Treg lineage, and by directly regulating the expansion and role of conventional T-cells.
Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, such as CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon- gamma (IFNG).
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Foxp3 |
| Uniprot: | Q99JB6 |
| Entrez: | 20371 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
AIID; AIIDMGC141961; human foxp3; mouse foxp3; DIETER; forkhead box P3; Forkhead Box Protein P3; foxp3 ihc; foxp3 paraffin; FoxP3; FOXP3delta7; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-Linked; IPEX; JM2; MGC141961; MGC141963; PIDX; PIDXMGC141963; SCURFIN; XPID; XPIDpolyendocrinopathy, enteropathy, X-linked
Molecular Weight
Mass (kDA):
47.346 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | X A1.1|X 3.41 cM |
| Sequence: | X; |
Tissue Specificity
High level of expression in thymus and spleen.
Diseases
- Autoimmune Reaction
- Inflammation
- Neoplasms
- Autoimmune Diseases
- Malignant Neoplasms
- Autoimmunity
- Decreased Immunologic Activity [pe]
- Diabetes Mellitus
- Carcinoma
- Diabetes Mellitus, Insulin-dependent
- Immunologic Tolerance
- Graft-vs-host Disease
- Intestinal Diseases
Pathways
- Immune Response
- Pathogenesis
- Secretion
- Cell Proliferation
- Cytokine Production
- T Cell Proliferation
- Cell Activation
- Cell Differentiation
- T Cell Activation
- Cell Development
- Tolerance Induction
- Hypersensitivity
- Inflammatory Response
PTMs
- Phosphorylation
- Methylation
- Demethylation
- Acetylation
- Cleavage
- Deamidation
- Deacetylation
- Ribosylation
- Reduction
Research Areas
- Adaptive Immunity
- Cell Biology
- Chromatin Research
- Immunology
- Regulatory Immunology
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Foxp3
bosterbio.com/bosterbio-gene-info-cards/Foxp3
References
PMID: 11138001 by Brunkow M.E., et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse.
PMID: 15790681 by Bettelli E., et al. Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells.
16 Publications of Boster Forkhead box protein P3 Antibodies & ELISA Kits
- PubMed ID: 10.1152/ajplung.00409.2016, Impaired TNF/TNFR2 signaling enhances Th2 and Th17 polarization and aggravates a...
- PubMed ID: 10.1021/acs.jafc.5b06177, Lactobacillus plantarum NCU116 Attenuates Cyclophosphamide-Induced Immunosuppres...
- PubMed ID: 10.1016/j.clim.2021.108914, Epigenetic regulation is involved in traffic-related PM2.5 aggravating allergic ...
- PubMed ID: 10.1016/j.bulcan.2014.09.003, Cooperative effect of Bifidobacteria lipoteichoic acid combined with 5-fluoroura...
- PubMed ID: 32724324, Wang Y,Zhang L,Li L,Hu H,Pan P,Zhang B,Ning W,Zhao M,Wang S.Electroacupuncture I...
- PubMed ID: 27698748, IL-35 improves Treg-mediated immune suppression in atherosclerotic mice
- PubMed ID: 27366089, Decreased FOXP3+ and GARP+ Tregs to neoadjuvant chemotherapy associated with fav...
- PubMed ID: 24289115, LncRNA DQ786243 affects Treg related CREB and Foxp3 expression in Crohn?s diseas...
- PubMed ID: 24498194, Wang B, Dai S, Dong Z, Sun Y, Song X, Guo C, Zhu F, Wang Q, Zhang L. Plos One. 2...
- PubMed ID: 25197340, Hu M, Li K, Maskey N, Xu Z, Peng C, Wang B, Li Y, Yang G. Int J Clin Exp Pathol....
- PubMed ID: 24080284, Gai Xd, Song Y, Li C, Lei Ym, Yang B. Pathol Res Pract. 2013 Dec;209(12):774-8. ...
- PubMed ID: 24648920, Gai Xd, Li C, Song Y, Lei Ym, Yang Bx. Biomed Rep. 2013 Mar;1(2):207-212. Epub 2...
- PubMed ID: 22749378, Fu Hy, Li C, Yang W, Gai Xd, Jia T, Lei Ym, Li Y. Acta Histochem. 2013 Mar;115(2...
- PubMed ID: 24369313, Li G, Ren J, Wang G, Gu G, Hu D, Ren H, Hong Z, Wu X, Liu S, Li J. Int Immunopha...
- PubMed ID: 26064167, Gong T, Wang Cf, Yuan Jr, Li Y, Gu Jf, Zhao Bj, Zhang L, Jia Xb, Feng L, Liu Sl....
- PubMed ID: 24573301, Xu D, Yu H, Yu Q, Wu S, Liu D, Lin Y, Zhang Y, Zheng C. Mol Med Rep. 2014 May;9(...
*More publications can be found for each product on its corresponding product page