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- Table of Contents
FUT2 Antibodies
AND FUT2 ELISA kits, FUT2 Proteins
Many biological assays use antibodies to detect FUT2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FUT2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FUT2 antibodies...
Designing an IHC experiment for FUT2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the FUT2 IHC GuideFUT2 Infographic by Boster Bio
All FUT2 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M02679
100 μg
Cat # M02679
100 μg
FUT2 Overview
Facts about Galactoside 2-alpha-L-fucosyltransferase 2.
Galactoside 2-alpha-L-fucosyltransferase 2 (FUT2)
Mediates the transfer of fucose into the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids (PubMed:7876235). The subsequent epitope plays a role in cell-cell interaction including host-microbe interaction (PubMed:12692541, PubMed:8018146).
Mediates interaction with intestinal microbiota influencing its composition (PubMed:21625510, PubMed:24733310, PubMed:22068912). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an important substrate for the last step in the soluble ABO blood group antigen synthesis pathway (PubMed:7876235).
Gene Information
| Human | |
|---|---|
| Gene Name: | FUT2 |
| Uniprot: | Q10981 |
| Entrez: | 2524 |
Family
| Belongs to: |
|---|
| glycosyltransferase 11 family |
Alternative Names
alpha (1,2) fucosyltransferase; Alpha(1,2)FT 2; alpha(1,2)FT2; B12QTL1; EC 2.4.1.69; fucosyltransferase 2 (secretor status included); Fucosyltransferase 2; FUT2; galactoside 2-alpha-L-fucosyltransferase 2; GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2; Se; Se2; SEC2; SEC2SE; Secretor blood group alpha-2-fucosyltransferase; Secretor factor; SEJ
Molecular Weight
Mass (kDA):
39.017 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.33 |
| Sequence: | 19; NC_000019.10 (48695971..48705951) |
Tissue Specificity
Small intestine, colon and lung.
Subcellular Localizations
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Membrane-bound form in trans cisternae of Golgi.
Diseases
- Malignant Neoplasms
- Tissue Adhesions
- Infective Disorder
- Neoplasms
- Gastroenteritis
- Crohn Disease
- Virus Diseases
- Malignant Neoplasm Of Stomach
- Malignant Tumor Of Colon
- Feline Urological Syndrome
- Helicobacter Infections
Pathways
- Fucosylation
- Glycosylation
- Pathogenesis
- Secretion
- Cell Adhesion
- Immune Response
- Gene Conversion
- Mating
- Estrus
- Insemination
- Localization
- Methylation
- Angiogenesis
PTMs
- Glycosylation
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FUT2
bosterbio.com/bosterbio-gene-info-cards/FUT2
References
PMID: 7876235 by Kelly R.J., et al. Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype.
PMID: 9219535 by Koda Y., et al. Structure and expression of the gene encoding secretor-type galactoside 2-alpha-L-fucosyltransferase (FUT2).