GABRB3 Antibodies

AND GABRB3 ELISA kits, GABRB3 Proteins

Many biological assays use antibodies to detect GABRB3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GABRB3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GABRB3 antibodies...

We validate the specificity of these antibodies to GABRB3 by testing them on tissues known to express GABRB3 positively and negatively. Browse below to find the GABRB3 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for GABRB3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the GABRB3 Western Blot Guide

GABRB3 Infographic by Boster Bio

All GABRB3 Products

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Anti-GABA A Receptor beta 3/GABRB3 Antibody Picoband®

Western blot analysis of GABRB3 using anti-GABRB3 antibody (PB9595)

Human, Mouse, Rat

$370
Cat # PB9595
100 μg/vial

GABRB3 Overview

Facts about Gamma-aminobutyric acid receptor subunit beta-3.

GABRB3 3D structure. Source: alphafold

Gamma-aminobutyric acid receptor subunit beta-3 (GABRB3)

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine.

Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel.

Gene Information

Human
Gene Name:	GABRB3
Uniprot:	P28472
Entrez:	2562

Family

Belongs to:

ligand-gated ion channel (TC 1.A.9) family

Alternative Names

ECA5; GABA A R beta 3; GABA(A) receptor beta-3 subunit; GABA(A) receptor subunit beta-3; GABAA receptor beta-3 subunit; GABA-alpha receptor beta-2 subunit; GABAAR beta 3; GABAARb3; GABRB3; gamma-aminobutyric acid (GABA) A receptor, beta 3; gamma-aminobutyric acid receptor subunit beta-3; MGC9051

Molecular Weight

Mass (kDA):
54.116 kDA

Genomic Context


Human

Location:	15q12
Sequence:	15; NC_000015.10 (26543546..26773763, complement)

Subcellular Localizations

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane.

Diseases

Angelman Syndrome
Autistic Disorder
Epilepsy
Prader-willi Syndrome
Dysequilibrium Syndrome
Uniparental Disomy
Absence Epilepsy
Cleft Palate
Cytogenetic Abnormality
Caprine Arthritis-encephalitis
Autism Spectrum Disorders

Nervousness
Epilepsy, Generalized
Depressive Disorder
Cleft Lip
Epilepsies, Myoclonic

Pathways

Methylation
Pathogenesis
Dna Methylation
Palate Development
Reflex
Meiosis I
Meiosis
Genetic Imprinting
Brain Development
Interphase
Synaptic Transmission
Localization
Dna Replication

Righting Reflex
Glycosylation
S Phase
Secretion
Meiosis Ii
Fertilization
Hypersensitivity

PTMs

Methylation

Phosphorylation

Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GABRB3

References

PMID: 1664410 by Wagstaff J., et al. The GABAA receptor beta 3 subunit gene: characterization of a human cDNA from chromosome 15q11q13 and mapping to a region of conserved synteny on mouse chromosome 7.

PMID: 8382702 by Kirkness E.F., et al. A strong promoter element is located between alternative exons of a gene encoding the human gamma-aminobutyric acid-type A receptor beta 3 subunit (GABRB3).