GFRAL Antibodies

AND GFRAL ELISA kits, GFRAL Proteins

Many biological assays use antibodies to detect GFRAL, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GFRAL in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GFRAL antibodies...

We validate the specificity of these antibodies to GFRAL by testing them on tissues known to express GFRAL positively and negatively. Browse below to find the GFRAL antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GFRAL Infographic by Boster Bio

All GFRAL Products

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Anti-GFRAL Reference Antibody (NGM120)

The purity of Anti-GFRAL Reference Antibody (NGM120)is more than 100%

Human

ELISA, Flow Cytometry, Functional Assay, Kinetics

$486
Cat # M13556
100 μg

GFRAL Overview

Facts about GDNF family receptor alpha-like.

GFRAL 3D structure. Source: alphafold

GDNF family receptor alpha-like (GFRAL)

Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.

Gene Information

Human
Gene Name:	GFRAL
Uniprot:	Q6UXV0
Entrez:	389400

Family

Belongs to:

GDNFR family

Alternative Names

GFR alpha like; GFR alpha-like; GFRAL; GRAL

Molecular Weight

Mass (kDA):
44.518 kDA

Genomic Context


Human

Location:	6p12.1
Sequence:	6; NC_000006.12 (55327469..55402493)

Tissue Specificity

Expressed in the brainstem, restricted to cells in the area postrema and the immediately adjacent region of the nucleus tractus solitarius (at protein level) (PubMed:28846097, PubMed:28846098). Detected at low levels in testis and adipose tissue (PubMed:28846097).

Subcellular Localizations

Cell membrane; Single-pass membrane protein; Extracellular side.

PTMs

Disulfide bond

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GFRAL

References

PMID: 28846097 by Mullican S.E., et al. GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates.

PMID: 28846099 by Yang L., et al. GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.