GJC2 Antibodies

AND GJC2 ELISA kits, GJC2 Proteins

Many biological assays use antibodies to detect GJC2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GJC2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GJC2 antibodies...

We validate the specificity of these antibodies to GJC2 by testing them on tissues known to express GJC2 positively and negatively. Browse below to find the GJC2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GJC2 Infographic by Boster Bio

All GJC2 Products

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Anti-GJC2 Antibody Picoband®

6 Q&As

Western blot analysis of GJC2 using anti-GJC2 antibody (PB9706)

Human, Mouse, Rat

$370
Cat # PB9706
100 μg/vial

Anti-CXG2 Antibody

Western Blot analysis of A549 cells using Connexin 47 Polyclonal Antibody

Immunofluorescence analysis of A549 cells, using CXG2 Antibody

Western blot analysis of lysates from A549 cells, using CXG2 Antibody

Human, Mouse, Rat

ELISA, IF, ICC, WB

$335
Cat # A30695
100ul

GJC2 Overview

Facts about Gap junction gamma-2 protein.

GJC2 3D structure. Source: alphafold

Gap junction gamma-2 protein (GJC2)

1 gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in peripheral and central nervous systems.

Gene Information

Human
Gene Name:	GJC2
Uniprot:	Q5T442
Entrez:	57165

Family

Belongs to:

connexin family

Alternative Names

connexin46.6; connexin-46.6; connexin-47; CX46.6; Cx47; Gap junction alpha-12 protein; gap junction gamma-2 protein; gap junction protein, alpha 12, 47kDa; gap junction protein, gamma 2, 47kDa; GJA12connexin 47; HLD2; LMPH1C; PMLDAR; SPG44MGC105119

Molecular Weight

Mass (kDA):
47.002 kDA

Genomic Context


Human

Location:	1q42.13
Sequence:	1; NC_000001.11 (228149930..228159826)

Tissue Specificity

Expressed in central nervous system, in sciatic nerve and sural nerve. Also detected in skeletal muscles.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Diseases

Pelizaeus-merzbacher Disease
Muscle Spasticity
Nystagmus
Leukodystrophy
Ataxia
Nervousness
Paraplegia
Spastic Paraplegia
Spastic Paraplegia, Hereditary
Leukoencephalopathies
Lymphedema

Demyelinating Diseases
Charcot-marie-tooth Disease
Milroy Disease
Peripheral Neuropathy
Impaired Cognition
Weakness

Pathways

Localization
Myelination

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GJC2

References

PMID: 15192806 by Uhlenberg B., et al. Mutations in the gene encoding gap junction protein alpha 12 (connexin 46.6) cause Pelizaeus-Merzbacher-like disease.

PMID: 19056803 by Orthmann-Murphy J.L., et al. Hereditary spastic paraplegia is a novel phenotype for GJA12/GJC2 mutations.