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- Table of Contents
Zinc finger protein GLI2 Antibodies
AND GLI2 ELISA kits, Zinc finger protein GLI2 Proteins
Many biological assays use antibodies to detect Zinc finger protein GLI2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Zinc finger protein GLI2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Zinc finger protein GLI2 antibodies...
Designing a Western blot for Zinc finger protein GLI2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the GLI2 Western Blot GuideGLI2 Infographic by Boster Bio
All GLI2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IHC, WB
$370
Cat # A00701-5
100 μg/vial
Cat # A00701-5
100 μg/vial
Human, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00701-6
100 µg/vial
Cat # A00701-6
100 µg/vial
GLI2 Overview
Facts about Zinc finger protein GLI2.
Zinc finger protein GLI2 (GLI2)
Functions as transcription regulator at the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as transcriptional activator (PubMed:9557682, PubMed:19878745, PubMed:24311597).
May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity.
Gene Information
| Human | |
|---|---|
| Gene Name: | GLI2 |
| Uniprot: | P10070 |
| Entrez: | 2736 |
Family
| Belongs to: |
|---|
| GLI C2H2-type zinc-finger protein family |
Alternative Names
GLI family zinc finger 2; GLI2; GLI-2; GLI-Kruppel family member GLI2; glioma-associated oncogene family zinc finger 2; HPE9tax helper protein 1; oncogene GLI2; tax helper protein 2; Tax helper protein; tax-responsive element-2 holding protein; tax-responsive element-25-bp sequence binding protein; THP; THP1; THP2; zinc finger protein GLI2
Molecular Weight
Mass (kDA):
167.783 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q14.2 |
| Sequence: | 2; NC_000002.12 (120735868..120992653) |
Tissue Specificity
Expressed in breast cancers (at protein level) (PubMed:26565916). Isoform 1 and isoform 4 are expressed in HTLV- 1-infected T-cell lines (at protein level) (PubMed:9557682). Isoform 1 and isoform 2 are strongly expressed in HTLV-1-infected T-cell lines (PubMed:9557682). Isoform 3 and isoform 4 are weakly expressed in HTLV-1-infected T-cell lines (PubMed:9557682).
Subcellular Localizations
Nucleus. Cytoplasm. Cell projection, cilium. STK36 promotes translocation to the nucleus. In keratinocytes, it is sequestered in the cytoplasm by SUFU. In the absence of SUFU, it translocates to the nucleus.; [Isoform 1]: Nucleus.; [Isoform 2]: Nucleus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Basal Cell Carcinoma
- Skin Neoplasms
- Malignant Paraganglionic Neoplasm
- Holoprosencephaly
- Hyperplasia
- Medulloblastoma
- Pituitary Diseases
- Carcinogenesis
Interacting Proteins
- BTRC
- SMAD3
Pathways
- Cell Proliferation
- Pathogenesis
- Localization
- Cell Cycle
- Transport
- Intraflagellar Transport
- Cell Growth
- Cell Differentiation
- Ossification
- Limb Development
- Cell Death
- Osteoblast Differentiation
- Chondrocyte Differentiation
PTMs
- Phosphorylation
- Cleavage
- Ubiquitination
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GLI2
bosterbio.com/bosterbio-gene-info-cards/GLI2
References
PMID: 9557682 by Tanimura A., et al. Cloning of novel isoforms of the human Gli2 oncogene and their activities to enhance tax-dependent transcription of the human T-cell leukemia virus type 1 genome.
PMID: 15994174 by Roessler E., et al. A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2.
2 Publications of Boster Zinc finger protein GLI2 Antibodies & ELISA Kits
- PubMed ID: PMID:28975979, GLI2 induces PDGFRB expression and modulates cancer stem cell properties of gast...
- PubMed ID: 10.1186/s12935-021-01775-5, Regulator of cullins-1 (ROC1) negatively regulates the Gli2 regulator SUFU to ac...
*More publications can be found for each product on its corresponding product page