Zinc finger protein GLIS2 (Glis2)

Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway.

Represses the Hedgehog-dependent expression of Wnt4. Necessary to keep the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which induces the epithelial-to- mesenchymal transition.