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- Table of Contents
Glutaredoxin-3 Antibodies
AND GLRX3 ELISA kits, Glutaredoxin-3 Proteins
Many biological assays use antibodies to detect Glutaredoxin-3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Glutaredoxin-3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Glutaredoxin-3 antibodies...
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GLRX3 Infographic by Boster Bio
All GLRX3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
WB
$523
Cat # M06489
100 µl
Cat # M06489
100 µl
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A06489
100 μg/vial
Cat # A06489
100 μg/vial
GLRX3 Overview
Facts about Glutaredoxin-3.
Glutaredoxin-3 (GLRX3)
Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity).
Required for hemoglobin maturation (PubMed:23615448). Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.
Gene Information
| Human | |
|---|---|
| Gene Name: | GLRX3 |
| Uniprot: | O76003 |
| Entrez: | 10539 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
FLJ11864; GLRX3; GLRX4; Glutaredoxin 3; glutaredoxin 4; glutaredoxin 5; GRX3; GRX4; PICOT; PICOTbA500G10.4; PKC-interacting cousin of thioredoxin; PKCq-interacting protein; thioredoxin-like 2; TXNL2; TXNL3
Molecular Weight
Mass (kDA):
37.432 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q26.3 |
| Sequence: | 10; NC_000010.11 (130136375..130182877) |
Tissue Specificity
Expressed in heart, spleen, testis and, to a lower extent, in thymus and peripheral blood leukocytes. Weakly expressed in lung, placenta, colon and small intestine.
Subcellular Localizations
Cytoplasm, cytosol. Cytoplasm, cell cortex. Cytoplasm, myofibril, sarcomere, Z line. Under the plasma membrane (By similarity). After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area (By similarity). In the Z line, found associated with CSRP3 (By similarity).
Diseases
- Malignant Neoplasms
- Hypertrophy
- Malignant Tumor Of Colon
- Cardiac Hypertrophy
- Carcinoma
- Neoplasms
- Cell Transformation, Neoplastic
- Lung Neoplasms
- Neoplasm Metastasis
- Metastatic Malignant Neoplasm To The Lung
- Malignant Neoplasm Of Breast
Pathways
- Cell Growth
- Cell Activation
- Dna Replication
- Cell Cycle
- Mitosis
- Regulation Of Signal Transduction
- S Phase
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GLRX3
bosterbio.com/bosterbio-gene-info-cards/GLRX3
References
PMID: 10636891 by Witte S., et al. Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain.
PMID: 11124703 by Stanchi F., et al. Characterization of 16 novel human genes showing high similarity to yeast sequences.