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- Table of Contents
Glutaredoxin-3 Antibodies
AND GLRX3 ELISA kits, Glutaredoxin-3 Proteins
Many biological assays use antibodies to detect Glutaredoxin-3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Glutaredoxin-3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Glutaredoxin-3 antibodies...
Designing a Western blot for Glutaredoxin-3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the GLRX3 Western Blot GuideGLRX3 Infographic by Boster Bio
All GLRX3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A06489
100 μg/vial
Cat # A06489
100 μg/vial
Human, Mouse, Rat
WB
$523
Cat # M06489
100 µl
Cat # M06489
100 µl
GLRX3 Overview
Facts about Glutaredoxin-3.
Glutaredoxin-3 (GLRX3)
Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity).
Required for hemoglobin maturation (PubMed:23615448). Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.
Gene Information
| Human | |
|---|---|
| Gene Name: | GLRX3 |
| Uniprot: | O76003 |
| Entrez: | 10539 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
FLJ11864; GLRX3; GLRX4; Glutaredoxin 3; glutaredoxin 4; glutaredoxin 5; GRX3; GRX4; PICOT; PICOTbA500G10.4; PKC-interacting cousin of thioredoxin; PKCq-interacting protein; thioredoxin-like 2; TXNL2; TXNL3
Molecular Weight
Mass (kDA):
37.432 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q26.3 |
| Sequence: | 10; NC_000010.11 (130136375..130182877) |
Tissue Specificity
Expressed in heart, spleen, testis and, to a lower extent, in thymus and peripheral blood leukocytes. Weakly expressed in lung, placenta, colon and small intestine.
Subcellular Localizations
Cytoplasm, cytosol. Cytoplasm, cell cortex. Cytoplasm, myofibril, sarcomere, Z line. Under the plasma membrane (By similarity). After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area (By similarity). In the Z line, found associated with CSRP3 (By similarity).
Diseases
- Malignant Neoplasms
- Hypertrophy
- Malignant Tumor Of Colon
- Cardiac Hypertrophy
- Carcinoma
- Neoplasms
- Cell Transformation, Neoplastic
- Lung Neoplasms
- Neoplasm Metastasis
- Metastatic Malignant Neoplasm To The Lung
- Malignant Neoplasm Of Breast
Pathways
- Cell Growth
- Cell Activation
- Dna Replication
- Cell Cycle
- Mitosis
- Regulation Of Signal Transduction
- S Phase
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GLRX3
bosterbio.com/bosterbio-gene-info-cards/GLRX3
References
PMID: 10636891 by Witte S., et al. Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain.
PMID: 11124703 by Stanchi F., et al. Characterization of 16 novel human genes showing high similarity to yeast sequences.