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- Table of Contents
GNL3 Antibodies
AND GNL3 ELISA kits, GNL3 Proteins
Many biological assays use antibodies to detect GNL3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GNL3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GNL3 antibodies...
Designing a Western blot for GNL3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the GNL3 Western Blot GuideDesigning an IHC experiment for GNL3? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the GNL3 IHC GuideGNL3 Infographic by Boster Bio
All GNL3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A03283-3
100 μg/vial
Cat # A03283-3
100 μg/vial
Human
Flow Cytometry, IF, ICC, WB
$370
Cat # M03283-1
100 μl/vial
Cat # M03283-1
100 μl/vial
GNL3 Overview
Facts about Guanine nucleotide-binding protein-like 3.
Guanine nucleotide-binding protein-like 3 (GNL3)
May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity).
.
Gene Information
| Human | |
|---|---|
| Gene Name: | GNL3 |
| Uniprot: | Q9BVP2 |
| Entrez: | 26354 |
Family
| Belongs to: |
|---|
| TRAFAC class YlqF/YawG GTPase family |
Alternative Names
C77032; E2IG3NNP47; estradiol-induced nucleotide binding protein; GNL3; guanine nucleotide binding protein-like 3 (nucleolar); guanine nucleotide-binding protein-like 3; MGC800; Novel nucleolar protein 47; NSE2-induced gene 3 protein; Nucleolar GTP-binding protein 3; Nucleostemin
Molecular Weight
Mass (kDA):
61.993 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p21.1 |
| Sequence: | 3; NC_000003.12 (52685920..52694497) |
Tissue Specificity
Increased levels in lung tissue in cancer patients.
Subcellular Localizations
Nucleus. Nucleus, nucleolus. Shuttles between the nucleus and nucleolus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Malignant Paraganglionic Neoplasm
- Malignant Squamous Cell Neoplasm
- Hyperplasia
- Neoplasm Metastasis
- Prostatic Neoplasms
- Malignant Neoplasm Of Prostate
- Esophageal Neoplasms
- Malignant Neoplasm Of Lung
- Lymphatic Metastasis
Interacting Proteins
- AGO2
- MDM2
- PPP2R5A
- STAT3
- TERT
Pathways
- Cell Cycle
- Cell Proliferation
- Cell Cycle Arrest
- Mitosis
- Localization
- S Phase
- Cell Differentiation
- Cell Growth
- Pathogenesis
- Aging
- Neurogenesis
- Interphase
- Oncogenesis
PTMs
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GNL3
bosterbio.com/bosterbio-gene-info-cards/GNL3
References
PMID: 11085516 by Charpentier A.H., et al. Effects of estrogen on global gene expression: identification of novel targets of estrogen action.
PMID: 16012751 by Han C., et al. Cloning of the nucleostemin gene and its function in transforming human embryonic bone marrow mesenchymal stem cells into F6 tumor cells.