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- Table of Contents
GPBAR1 Antibodies
AND GPBAR1 ELISA kits, GPBAR1 Proteins
Many biological assays use antibodies to detect GPBAR1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GPBAR1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GPBAR1 antibodies...
Designing a Western blot for GPBAR1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the GPBAR1 Western Blot GuideGPBAR1 Infographic by Boster Bio
All GPBAR1 Products
Product
Figures
Specificity
Applications
Price
Anti-GPCR TGR5/GPBAR1 Antibody Picoband®
1 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A01958-2
100 μg/vial
Cat # A01958-2
100 μg/vial
GPBAR1 Overview
Facts about G-protein coupled bile acid receptor 1.
G-protein coupled bile acid receptor 1 (GPBAR1)
Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production.
May be involved in the suppression of macrophage functions by bile acids. .
Gene Information
| Human | |
|---|---|
| Gene Name: | GPBAR1 |
| Uniprot: | Q8TDU6 |
| Entrez: | 151306 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 1 family |
Alternative Names
BG37; BG37hBG37; G protein-coupled bile acid receptor 1; GPBA; GPBAR1; GPCR19; GPR131; G-protein coupled bile acid receptor 1; G-protein coupled bile acid receptor BG37; G-protein coupled receptor GPCR19; M-BAR; M-BARhGPCR19; membrane bile acid receptor; Membrane-type receptor for bile acids; MGC40597; TGR5; TGR5GPCR
Molecular Weight
Mass (kDA):
35.248 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q35 |
| Sequence: | 2; NC_000002.12 (218259496..218263861) |
Tissue Specificity
Ubiquitously expressed. Expressed at higher level in spleen and placenta. Expressed at lower level in other tissues. In digestive tissues, it is expressed in stomach, duodenum, ileocecum, ileum, jejunum, ascending colon, transverse colon, descending colon, cecum and liver, but not in esophagus and rectum.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein.
Diseases
- Obesity
- Diabetes Mellitus
- Metabolic Diseases
- Diabetes Mellitus, Non-insulin-dependent
- Liver Diseases
- Inflammation
- Cholecystolithiasis
- Insulin Resistance
- Atherosclerosis
- Insulin Sensitivity
- Fatty Liver
- Cholestasis
- Biliary Tract Diseases
Pathways
- Secretion
- Glucose Homeostasis
- Energy Homeostasis
- Cholesterol Homeostasis
- Cell Proliferation
- Localization
- Transport
- Liver Regeneration
- Regeneration
- Gallstone Formation
- Cytokine Production
- Pathogenesis
- Programmed Cell Death
PTMs
- Phosphorylation
- Oxidation
Research Areas
- GPCR
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GPBAR1
bosterbio.com/bosterbio-gene-info-cards/GPBAR1
References
PMID: 12419312 by Maruyama T., et al. Identification of membrane-type receptor for bile acids (M-BAR).
PMID: 12524422 by Kawamata Y., et al. A G protein-coupled receptor responsive to bile acids.