Glypican-6 Antibodies

AND GPC6 ELISA kits, Glypican-6 Proteins

Many biological assays use antibodies to detect Glypican-6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Glypican-6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Glypican-6 antibodies...

We validate the specificity of these antibodies to Glypican-6 by testing them on tissues known to express GPC6 positively and negatively. Browse below to find the GPC6 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GPC6 Infographic by Boster Bio

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Glypican 6 (GPC6) (NM_005708) Human Over-expression Lysate

Human

$960
Cat # LS010082
20 µg, 100 µg

GPC6 Overview

Facts about Glypican-6.

GPC6 3D structure. Source: alphafold

Glypican-6 (GPC6)

Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity).

Enhances migration and invasion of cancer cells through WNT5A signaling. .

Gene Information

Human
Gene Name:	GPC6
Uniprot:	Q9Y625
Entrez:	10082

Family

Belongs to:

glypican family

Alternative Names

Glypican 6; glypican proteoglycan 6; glypican-6; GPC6; MGC126288; OMIMD1

Molecular Weight

Mass (kDA):
62.736 kDA

Genomic Context


Human

Location:	13q31.3-q32.1
Sequence:	13; NC_000013.11 (93226807..94408020)

Tissue Specificity

Widely expressed. High expression in fetal kidney and lung and lower expressions in fetal liver and brain. In adult tissues, very abundant in ovary, high levels also observed in liver, kidney, small intestine and colon. Not detected in peripheral blood leukocytes. Detected in breast cancer cells (at protein level).

Subcellular Localizations

Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.; [Secreted glypican-6]: Secreted, extracellular space.

Diseases

Neoplasms
Simpson-golabi-behmel Syndrome, Type 1
Malignant Neoplasms
Carcinoma
Growth Arrest
Neoplasm Metastasis
Malignant Neoplasm Of Breast
Dementia
Dystrophia Unguium
Neoplasm Invasiveness
Sarcoma
Ulcer

Dwarfism
Mammary Neoplasms
Retinal Neoplasms
Anxiety Disorders
Hereditary Diseases
Chromosomal Duplication
Intrahepatic Cholangiocarcinoma

Pathways

Cell Growth
Sulfation
Cell Division
Endochondral Ossification
Cell Proliferation
Receptor Clustering
Osteoblast Proliferation
Ossification

Pathogenesis
Chondrocyte Differentiation

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GPC6

References

PMID: 10329016 by Paine-Saunders S., et al. GPC6, a novel member of the glypican gene family, encodes a product structurally related to GPC4 and is colocalized with GPC5 on human chromosome 13.

PMID: 10480909 by Veugelers M., et al. Glypican-6, a new member of the glypican family of cell surface heparan sulfate proteoglycans.