Harmonin Antibodies

AND USH1C ELISA kits, Harmonin Proteins

Many biological assays use antibodies to detect Harmonin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Harmonin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Harmonin antibodies...

We validate the specificity of these antibodies to Harmonin by testing them on tissues known to express USH1C positively and negatively. Browse below to find the USH1C antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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USH1C Infographic by Boster Bio

All USH1C Products

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Specificity

Applications

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Anti-Harmonin USH1C Antibody

Western blot analysis of extracts of various cell lines, using USH1C antibody

Human, Mouse, Rat

$405
Cat # A03467
100ul

Human Harmonin Recombinant Protein

SDS-PAGE

$250
Cat # PROTQ9Y6N9
Starting from 20ug

Anti-USH1C Mouse Monoclonal Antibody [Clone ID: OTI1H8]

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY USH1C (Right lane) cDNA for 48 hrs and lysed

Human, Mouse

$523
Cat # M03467
100 µl

USH1C (NM_153676) Human Over-expression Lysate

Human

$960
Cat # LS010083
20 µg, 100 µg

USH1C Overview

Facts about Harmonin.

USH1C 3D structure. Source: alphafold

Harmonin (USH1C)

Anchoring/scaffolding protein that is a part of the operational network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles (By similarity).

As part of the intermicrovillar adhesion complex/IMAC plays a part in brush border differentiation, controlling microvilli organization and span. Probably plays a central regulatory role in the assembly of the complex, recruiting CDHR2, CDHR5 and MYO7B into the microvilli tips (PubMed:24725409, PubMed:26812018).

Gene Information

Human
Gene Name:	USH1C
Uniprot:	Q9Y6N9
Entrez:	10083

Family

Belongs to:

No superfamily

Alternative Names

AIE75; AIE-75; Antigen NY-CO-38/NY-CO-37; Autoimmune enteropathy-related antigen AIE-75; deafness, autosomal recessive 18; DFNB18; harmonin; NY-CO-37; NY-CO-38; PDZ-45; PDZ73; PDZ-73; PDZ-73/NY-CO-38; Protein PDZ-73; Renal carcinoma antigen NY-REN-3; ush1cpst; Usher syndrome 1C (autosomal recessive, severe); Usher syndrome type-1C protein

Molecular Weight

Mass (kDA):
62.211 kDA

Genomic Context


Human

Location:	11p15.1
Sequence:	11; NC_000011.10 (17493895..17544416, complement)

Tissue Specificity

Expressed in small intestine, colon, kidney, eye and weakly in pancreas. Expressed also in vestibule of the inner ear.

Subcellular Localizations

Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell projection, microvillus. Colocalizes with F-actin (By similarity). Detected at the tip of cochlear hair cell stereocilia (By similarity). Enriched in microvilli of the intestinal brush border (PubMed:24725409).