Harmonin (USH1C)

Anchoring/scaffolding protein that is a part of the operational network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles (By similarity).

As part of the intermicrovillar adhesion complex/IMAC plays a part in brush border differentiation, controlling microvilli organization and span. Probably plays a central regulatory role in the assembly of the complex, recruiting CDHR2, CDHR5 and MYO7B into the microvilli tips (PubMed:24725409, PubMed:26812018).