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- Table of Contents
Gephyrin Antibodies
AND GPHN ELISA kits, Gephyrin Proteins
Many biological assays use antibodies to detect Gephyrin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Gephyrin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Gephyrin antibodies...
Designing a Western blot for Gephyrin? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the GPHN Western Blot GuideGPHN Infographic by Boster Bio
All GPHN Products
Product
Figures
Specificity
Applications
Price
Human, Monkey, Mouse, Rat
ELISA, IF, IHC, ICC, WB
$370
Cat # A04560-1
100 μg/vial
Cat # A04560-1
100 μg/vial
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M04560-3
100 μl/vial
Cat # M04560-3
100 μl/vial
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$523
Cat # M04560
100 µl
Cat # M04560
100 µl
Human, Mouse, Rat
Flow Cytometry, IF, WB
$523
Cat # M04560-1
100 µl
Cat # M04560-1
100 µl
Human, Monkey, Mouse, Rat
Flow Cytometry, WB
$523
Cat # M04560-2
100 µl
Cat # M04560-2
100 µl
GPHN Overview
Facts about Gephyrin.
Gephyrin (GPHN)
Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It's supposed to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules.
Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated.
Gene Information
| Human | |
|---|---|
| Gene Name: | GPHN |
| Uniprot: | Q9NQX3 |
| Entrez: | 10243 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
GEPH; Gephyrin; GPH; GPHN; GPHRYN; KIAA1385GPHGEPH
Molecular Weight
Mass (kDA):
79.748 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q23.3-q24.1 |
| Sequence: | 14; NC_000014.9 (66507934..67181805) |
Subcellular Localizations
Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, dendrite. Cell junction, synapse, postsynaptic density. Cytoplasmic face of glycinergic postsynaptic membranes.
Diseases
- Hyperexplexia
- Muscle Hypertonia
- Combined Molybdoflavoprotein Enzyme Deficiency
- Nervous System Disorder
- Leukemia
- Mutation, Out-of-frame
- Apnea
- Chromosomal Translocation
- Paraplegia
- Leukemogenesis
- Spastic Paraplegia
Interacting Proteins
- DYNLL1
Pathways
- Startle Response
- Localization
- Chromosome Localization
- Error-prone Dna Repair
- Dna Repair
- Synaptic Transmission
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GPHN
bosterbio.com/bosterbio-gene-info-cards/GPHN
References
PMID: 10839351 by Butler M.H., et al. Autoimmunity to gephyrin in Stiff-Man syndrome.
PMID: 11095995 by Reiss J., et al. A mutation in the gene for the neurotransmitter receptor-clustering protein gephyrin causes a novel form of molybdenum cofactor deficiency.