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GPR37L1 Antibodies
AND GPR37L1 ELISA kits, GPR37L1 Proteins
Many biological assays use antibodies to detect GPR37L1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GPR37L1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GPR37L1 antibodies...
Designing an IHC experiment for GPR37L1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the GPR37L1 IHC GuideGPR37L1 Infographic by Boster Bio
All GPR37L1 Products
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GPR37L1 Overview
Facts about G-protein coupled receptor 37-like 1.
G-protein coupled receptor 37-like 1 (GPR37L1)
G-protein coupled receptor (PubMed:27072655). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (PubMed:23690594).
However, other studies have shown that prosaposin doesn't increase action (PubMed:27072655, PubMed:28688853). It's been suggested that GPR37L1 is a constitutively active receptor that signals through the guanine nucleotide-binding protein G(s) subunit alpha (PubMed:27072655).
Gene Information
| Human | |
|---|---|
| Gene Name: | GPR37L1 |
| Uniprot: | O60883 |
| Entrez: | 9283 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 1 family |
Alternative Names
endothelin B receptor-like protein 2; ET(B)R-LP-2; ETBRLP2; ETBR-LP-2; ETBR-LP-2endothelin type b receptor-like protein 2; G protein-coupled receptor 37 like 1; GPR37L1; G-protein coupled receptor 37 like 1; G-protein coupled receptor 37-like 1
Molecular Weight
Mass (kDA):
52.771 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q32.1 |
| Sequence: | 1; NC_000001.11 (202118669..202133592) |
Tissue Specificity
Expressed in primary cortical astrocytes (at protein level) (PubMed:23690594). Expressed in the central nervous system (PubMed:9539149).
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Cell projection, cilium membrane; Multi-pass membrane protein. Associates with the basal membrane of Bergmann glia cell primary cilia.
Diseases
- Autistic Disorder
- Tumor Angiogenesis
- Heart Diseases
- Heart Failure
- Cardiac Arrest
- Atherosclerosis
- Coronary Artery Disease
Interacting Proteins
- PRCP
Pathways
- Methylation
- Tube Closure
- Neural Tube Closure
- Brain Development
- Regulation Of Secretion
- Angiogenesis
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GPR37L1
bosterbio.com/bosterbio-gene-info-cards/GPR37L1
References
PMID: 9539149 by Valdenaire O., et al. A new family of orphan G protein-coupled receptors predominantly expressed in the brain.
PMID: 23690594 by Meyer R.C., et al. GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin.