Growth factor receptor-bound protein 10 (GRB10)

Adapter protein that modulates coupling of a number of cell surface receptor kinases with particular signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors.

The inhibitory effect can be achieved by two mechanisms: interference with the signaling pathway and enhanced receptor degradation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin- stimulated IRS1 and IRS2 tyrosine phosphorylation.