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- Table of Contents
GRHL2 Antibodies
AND GRHL2 ELISA kits, GRHL2 Proteins
Many biological assays use antibodies to detect GRHL2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GRHL2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GRHL2 antibodies...
Designing a Western blot for GRHL2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the GRHL2 Western Blot GuideDesigning an IHC experiment for GRHL2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the GRHL2 IHC GuideGRHL2 Infographic by Boster Bio
All GRHL2 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A04120-2
100 μg/vial
Cat # A04120-2
100 μg/vial
GRHL2 Overview
Facts about Grainyhead-like protein 2 homolog.
Grainyhead-like protein 2 homolog (GRHL2)
Transcription factor playing an essential role in primary neurulation and in epithelial development (PubMed:29309642, PubMed:25152456). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (By similarity).
During embryogenesis, plays with unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation. Essential for closing 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closed 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | GRHL2 |
| Uniprot: | Q6ISB3 |
| Entrez: | 79977 |
Family
| Belongs to: |
|---|
| grh/CP2 family |
Alternative Names
BOMMGC149294; Brother of mammalian grainyhead; deafness, autosomal dominant 28; DFNA28; FLJ13782; grainyhead-like 2 (Drosophila); grainyhead-like protein 2 homolog; TFCP2L3MGC149295; Transcription factor CP2-like 3FLJ11172
Molecular Weight
Mass (kDA):
71.105 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q22.3 |
| Sequence: | 8; NC_000008.11 (101492439..101678104) |
Tissue Specificity
Expressed in keratinocytes (at protein level). Highly expressed in placenta, prostate, brain and kidney. Lower- level expression in a variety of epithelial tissues such as thymus, lung, salivary gland, mammary gland and digestive tract. Expressed in the cochlear.
Subcellular Localizations
Nucleus. Membrane. detected at cell-cell contact areas.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Congenital Abnormality
- Tissue Adhesions
- Neoplasm Metastasis
- Carcinoma
- Mammary Neoplasms
- Presbycusis
- Stenosis
- Diabetic Nephropathy
- Tumor Progression
Interacting Proteins
- LMO4
Pathways
- Neural Tube Closure
- Tube Closure
- Cell Proliferation
- Cell Migration
- Wound Healing
- Cell Morphogenesis
- Localization
- Transport
- Cell Adhesion
- Organic Acid Transport
- Dorsal Closure
- Tube Fusion
- Keratinocyte Differentiation
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GRHL2
bosterbio.com/bosterbio-gene-info-cards/GRHL2
References
PMID: 12393799 by Peters L.M., et al. Mutation of a transcription factor, TFCP2L3, causes progressive autosomal dominant hearing loss, DFNA28.
PMID: 12175488 by Wilanowski T., et al. A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead.