Glutamate receptor ionotropic, NMDA 2C (GRIN2C)

Part of NMDA receptor complexes which function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate into the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:26875626).

Sensitivity to glutamate and channel kinetics are determined by the subunit composition (Probable). Plays a role in controlling the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex.