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- Table of Contents
Facts about Glutamate receptor ionotropic, NMDA 2C.
Sensitivity to glutamate and channel kinetics are determined by the subunit composition (Probable). Plays a role in controlling the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex.
Human | |
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Gene Name: | GRIN2C |
Uniprot: | Q14957 |
Entrez: | 2905 |
Belongs to: |
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glutamate-gated ion channel (TC 1.A.10.1) family |
glutamate [NMDA] receptor subunit epsilon-3; glutamate receptor, ionotropic, N-methyl D-aspartate 2C; GRIN2C; NMDA R, NR2C Subunit; NMDAR2C; NMDAR2CNR2C; N-methyl D-aspartate receptor subtype 2C; N-methyl-D-aspartate receptor subunit 2C; NR2C
Mass (kDA):
134.209 kDA
Human | |
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Location: | 17q25.1 |
Sequence: | 17; NC_000017.11 (74842021..74860843, complement) |
Mainly expressed in brain with predominant expression is in the cerebellum, also present in the hippocampus, amygdala, caudate nucleus, corpus callosum, subthalamic nuclei and thalamus. Detected in the heart, skeletal muscle and pancreas.
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
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You may be interested in Steven Boster's background if you are a biomedical research scientist. Steve was a career scientist who loved immunology. His research and development have helped scientists around the world perform hundreds of ELISA test. Boster created his first product in 1993. Since then, he has created hundreds of primary antibodies as well as products for immunohistochemistry. Steven had already become one the largest Chinese antibody catalog companies by mid-nineties. The company later developed its proprietary ELISA platform, PicoKine(tm), and delivers high-sensitivity ELISA kits.
Steve Boster, a Joliet resident, was born September 6, 1926. He was the eldest son of James Meier, and an Army veteran. He was a member of Concordia Hall in Staunton, VA, and was survived by his two daughters, Crystal Boster and Natosha Peck. He also leaves behind four brothers, Jack Boster and Sandra Blanton, along with a sister, Lisa Milton. Numerous nieces or nephews also survive him.
The GRIN2C markers are used to identify cells expressing NR2C subunits. This protein is 140 kDa long and is a part of the NMDA receiver family. Recent studies have shown that GRIN2C plays a role in the pathogenesis ASD/SCZ. It is therefore an important diagnostic tool to aid in the diagnosis and treatment of these conditions.
This gene also contains a 5'-exon junction alternative that is more extensive and elongated than the canonical. This resulted is alternative translation starts, and an insertion 21 aa into LBD S2 segment. These junctions are found in a large number human datasets but not in mice or rats. NMD is also possible for several other junctions.
PMID: 9037519 by Lin Y.J., et al. Cloning of the cDNA for the human NMDA receptor NR2C subunit and its expression in the central nervous system and periphery.
PMID: 21300787 by Cai L., et al. Deficiency of sorting nexin 27 (SNX27) leads to growth retardation and elevated levels of N-methyl-D-aspartate receptor 2C (NR2C).