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- Table of Contents
Facts about Beta-glucuronidase.
Human | |
---|---|
Gene Name: | GUSB |
Uniprot: | P08236 |
Entrez: | 2990 |
Belongs to: |
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glycosyl hydrolase 2 family |
beta-D-glucuronidase; Beta-G1; beta-glucuronidase; BG; EC 3.2.1.31; FLJ39445; glucuronidase, beta; GUSB; MPS7
Mass (kDA):
74.732 kDA
Human | |
---|---|
Location: | 7q11.21 |
Sequence: | 7; NC_000007.14 (65960684..65982230, complement) |
Lysosome.
The Anti-beta glucuronidase/GUSB antibody is expressed from Baculovirus with a His-Tag. Its sequence domain is from 23-651aa. Its use is in SDS-PAGE and enzyme activity assays. The human GUSB protein can be stored at 2-8degC for one week or -20degC to -80degC. However, it is advisable to avoid repeated freeze-thacility cycles. Scientists can get product credits by sharing their results.
The GUSB marker is a gene whose expression is associated with the presence of mucopolysaccharidosis. It is required for carbohydrate binding and metabolism. The enzyme is found in the lysosome and is a biomarker for mucopolysaccharidosis. It is also implicated in Sly syndrome and mucopolysaccharide-resistant lipoprotein dehydrogenase.
The Anti-beta glucuronidese/GUSB antibody from Boster Bio is part of the Picoband(tm) catalog and reacts with Human. It is also available as blocking peptide, but the immunogen length and price vary. This product is stable at -20°C for a year. Before you begin using it, you should know that it should be stored at -20 degrees Celsius.
This antibody recognizes beta-glucuronidase, an enzyme that degrades glycosaminoglycans. The protein is found in the lysosome, where it catalyzes the breakdown of complex carbohydrates. It is found in a homotetramer and is localized in the lysosome. Mucopolysis type VII is caused by mutations in this gene. In mucopolysis patients, partially degraded glycosaminoglycans are often found in the lysosomes.
Recombinant human GUSB protein is a purified form of the gene that encodes the glucuronidase beta protein. It has a mass of approximately 74.7 kilodaltons and has orthologs in E. coli, mouse, rat, and fly. It is also available as a blocking peptide to reduce cost. In addition to the purified protein, Boster also offers anti-GUSB antibodies.
PMID: 3468507 by Oshima A., et al. Cloning, sequencing, and expression of cDNA for human beta- glucuronidase.
PMID: 1916806 by Shipley J.M., et al. Analysis of the 5' flanking region of the human beta-glucuronidase gene.