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- Table of Contents
GATM Antibodies
AND GATM ELISA kits, GATM Proteins
Many biological assays use antibodies to detect GATM, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GATM in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GATM antibodies...
Designing an IHC experiment for GATM? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the GATM IHC GuideGATM Infographic by Boster Bio
All GATM Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, WB
$370
Cat # A02754-1
100 μg/vial
Cat # A02754-1
100 μg/vial
GATM Overview
Facts about Glycine amidinotransferase, mitochondrial.
Glycine amidinotransferase, mitochondrial (GATM)
Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues.
May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis.
Gene Information
| Human | |
|---|---|
| Gene Name: | GATM |
| Uniprot: | P50440 |
| Entrez: | 2628 |
Family
| Belongs to: |
|---|
| amidinotransferase family |
Alternative Names
AGATtransamidinase; AT; EC 2.1.4; EC 2.1.4.1; glycine amidinotransferase (L-arginine:glycine amidinotransferase); glycine amidinotransferase, mitochondrial; L-arginine:glycine amidinotransferase; Transamidinase
Molecular Weight
Mass (kDA):
48.455 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 15q21.1 |
| Sequence: | 15; NC_000015.10 (45361124..45402227, complement) |
Tissue Specificity
Expressed in brain, heart, kidney, liver, lung, salivary gland and skeletal muscle tissue, with the highest expression in kidney. Biallelically expressed in placenta and fetal tissues.
Subcellular Localizations
[Isoform 1]: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Probably attached to the outer side of the inner membrane.; [Isoform 2]: Cytoplasm.
Diseases
- Malignant Neoplasms
- Lung Neoplasms
- Diabetes Mellitus
- Aneurysm
- Pregnancy Complications
- Weakness
- Endometrial Polyp
- Pre-eclampsia
- Malignant Neoplasm Of Lung
- Fetal Growth Retardation
- Mastitis
Pathways
- Transport
- Methylation
- Cell Adhesion
- Gastrulation
- Cell Proliferation
- Proteolysis
- Dna Methylation
- Glomerular Filtration
- Regeneration
- Endocrine Signaling
- Tissue Remodeling
PTMs
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GATM
bosterbio.com/bosterbio-gene-info-cards/GATM
References
PMID: 8313955 by Humm A., et al. The amino acid sequences of human and pig L-arginine:glycine amidinotransferase.
PMID: 3800397 by Gross M.D., et al. The purification and characterization of human kidney L- arginine:glycine amidinotransferase.