Zinc finger protein GLIS2 Antibodies

AND Glis2 ELISA kits, Zinc finger protein GLIS2 Proteins

Many biological assays use antibodies to detect Zinc finger protein GLIS2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Zinc finger protein GLIS2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Zinc finger protein GLIS2 antibodies...

We validate the specificity of these antibodies to Zinc finger protein GLIS2 by testing them on tissues known to express Glis2 positively and negatively. Browse below to find the Glis2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Glis2 Infographic by Boster Bio

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Anti-Zinc finger protein GLIS2 GLIS2 Antibody

Western blot analysis of GLIS2 in K562 cell lysate with GLIS2 antibody at 1 μg/ml

Immunohistochemistry of GLIS2 in mouse kidney tissue with GLIS2 antibody at 5 μg/ml

Human, Mouse, Rat

ELISA, IHC-P, WB

$481
Cat # A07390
0.1 mg

GLIS2 (NM_032575) Human Over-expression Lysate

Human

$960
Cat # LS084662
20 µg, 100 µg

Glis2 Overview

Facts about Zinc finger protein GLIS2.

Zinc finger protein GLIS2 (Glis2)

Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway.

Represses the Hedgehog-dependent expression of Wnt4. Necessary to keep the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which induces the epithelial-to- mesenchymal transition.

Gene Information

Mouse
Gene Name:	Glis2
Uniprot:	Q8VDL9
Entrez:	83396

Family

Belongs to:

GLI C2H2-type zinc-finger protein family

Alternative Names

GLIS family zinc finger 2; NKL; zinc finger protein GLIS2

Molecular Weight

Mass (kDA):
55.842 kDA

Genomic Context


Mouse

Location:	16 A1\|16 2.45 cM
Sequence:	16;

Tissue Specificity

Expressed at high levels in kidney, and at lower levels in heart and lung.

Diseases

Kidney Diseases
Nephronophthisis
Cystic Kidney Diseases
Fibrosis
Atrophy
Kidney Failure, Chronic
Diabetes Mellitus
Renal Atrophy
Congenital Hypothyroidism
Chronic Kidney Disease
Hypothyroidism
Kidney Failure
Polycystic Kidney Diseases

Hepatic Fibrosis
Congenital Cerebellar Hypoplasia
Retinal Degeneration
Familial Aplasia Of The Vermis
Congenital Anomaly Of Face
Malignant Neoplasms
Situs Inversus

Pathways

Pathogenesis
Kidney Development
Cell Death
Neurogenesis
Regulation Of Gene Expression
Localization

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Glis2

References

PMID: 11262234 by Lamar E., et al. Identification of NKL, a novel Gli-Kruppel zinc-finger protein that promotes neuronal differentiation.

PMID: 11741991 by Zhang F., et al. Characterization of Glis2, a novel gene encoding a Gli-related, Kruppel-like transcription factor with transactivation and repressor functions. Roles in kidney development and neurogenesis.