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- Table of Contents
HAT1 Antibodies
AND HAT1 ELISA kits, HAT1 Proteins
Many biological assays use antibodies to detect HAT1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HAT1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HAT1 antibodies...
Designing a Western blot for HAT1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the HAT1 Western Blot GuideHAT1 Infographic by Boster Bio
All HAT1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # A03596-2
100 μg/vial
Cat # A03596-2
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M03596
100 μl/vial
Cat # M03596
100 μl/vial
Human, Mouse, Rat
ELISA
$480
Cat # EKC1257
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1257
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA, IF, IHC-P, WB
$481
Cat # A01213
0.1 mg
Cat # A01213
0.1 mg
HAT1 Overview
Facts about Histone acetyltransferase type B catalytic subunit.
Histone acetyltransferase type B catalytic subunit (HAT1)
Acetylates soluble but not nucleosomal histone H4 at'Lys-5' (H4K5ac) and'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at'Lys-5' (H2AK5ac). Has inherent substrate specificity that modifies lysine in recognition sequence GXGKXG.
May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.
Gene Information
| Human | |
|---|---|
| Gene Name: | HAT1 |
| Uniprot: | O14929 |
| Entrez: | 8520 |
Family
| Belongs to: |
|---|
| HAT1 family |
Alternative Names
EC 2.3.1.48; histone acetyltransferase 1; histone acetyltransferase type B catalytic subunit; KAT1
Molecular Weight
Mass (kDA):
49.513 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q31.1 |
| Sequence: | 2; NC_000002.12 (171922425..171983686) |
Subcellular Localizations
[Isoform A]: Nucleus matrix.; [Isoform B]: Cytoplasm. Nucleus. Nucleus matrix. Nucleus, nucleoplasm. Localization is predominantly nuclear in normal cells. Treatment with hydrogen peroxide or ionizing radiation enhances nuclear localization through redistribution of existing protein.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Lung
- Traditional Serrated Adenoma
- Hyperplasia
- Heparin-induced Thrombocytopenia
- Multiple Organ Failure
- Dna Injury
- Curvature Of Spine
- Colonic Neoplasms
Interacting Proteins
- HIST1H4A
- MEOX2
- RBBP4
- REL
- TCF4
- TNFAIP1
Pathways
- Chromatin Assembly
- Histone Acetylation
- Methylation
- Histone Modification
- Cell Cycle
- Chromatin Remodeling
- Cell Proliferation
- Dna Repair
- Nucleosome Assembly
- Dna Replication
- Transport
- Nuclear Import
- Dna Methylation
PTMs
- Acetylation
- Methylation
Research Areas
- Core ESC-Like Genes
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HAT1
bosterbio.com/bosterbio-gene-info-cards/HAT1
References
PMID: 9427644 by Verreault A., et al. Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase.
PMID: 11585814 by Makowski A.M., et al. Effects of acetylation of histone H4 at lysines 8 and 16 on activity of the Hat1 histone acetyltransferase.