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- Table of Contents
Histone deacetylase 8 Antibodies
AND HDAC8 ELISA kits, Histone deacetylase 8 Proteins
Many biological assays use antibodies to detect Histone deacetylase 8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Histone deacetylase 8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Histone deacetylase 8 antibodies...
Designing a Western blot for Histone deacetylase 8? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the HDAC8 Western Blot GuideHDAC8 Infographic by Boster Bio
All HDAC8 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$370
Cat # PA1591
100 μg/vial
Cat # PA1591
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IP, IF, ICC, WB
$370
Cat # M01843-1
100 μl
Cat # M01843-1
100 μl
Human
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M01843
100 μl
Cat # M01843
100 μl
Human, Mouse, Rat
ELISA
$540
Cat # EKC2425
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2425
1 kit, containing two 96-well plates and all necessary reagents
Human
Flow Cytometry, IP, IF, IHC, ICC, WB
$405
Cat # A01843
100ul
Cat # A01843
100ul
Human, Mouse, Rat
ELISA
$480
Cat # EKC1268
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1268
1 kit, containing one 96-well plate and all necessary reagents
HDAC8 Overview
Facts about Histone deacetylase 8.
Histone deacetylase 8 (HDAC8)
Responsible for the deacetylation of lysine residues on the N-terminal portion of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Histone deacetylases act via the formation of large multiprotein complexes. Also included in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin.
Gene Information
| Human | |
|---|---|
| Gene Name: | HDAC8 |
| Uniprot: | Q9BY41 |
| Entrez: | 55869 |
Family
| Belongs to: |
|---|
| histone deacetylase family |
Alternative Names
EC 3.5.1.98; HD8; HDAC8; HDACL1; Histone Deacetylase 8; histone deacetylase-like 1; RPD3
Molecular Weight
Mass (kDA):
41.758 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xq13.1 |
| Sequence: | X; NC_000023.11 (72329516..72573103, complement) |
Tissue Specificity
Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney.
Subcellular Localizations
Nucleus. Cytoplasm. Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation.
Diseases
- Malignant Neoplasms
- Neoplasms
- Traditional Serrated Adenoma
- Leukemia
- Malignant Neoplasm Of Breast
- Neuroblastoma
- Malignant Neoplasm Of Prostate
- Malignant Tumor Of Colon
- Inflammation
- Colonic Neoplasms
- Malignant Paraganglionic Neoplasm
- Cell Transformation, Neoplastic
Pathways
- Histone Acetylation
- Cell Proliferation
- Cell Cycle
- Methylation
- Cell Growth
- Pathogenesis
- Regulation Of Gene Expression
- Cell Cycle Arrest
- Cell Differentiation
- Localization
- Rna Interference
- Nuclear Export
- Induction Of Apoptosis
PTMs
- Acetylation
- Deacetylation
- Phosphorylation
- Methylation
Research Areas
- Breast Cancer
- Cancer
- Chromatin Research
- Epigenetics
- Phospho-Specific
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HDAC8
bosterbio.com/bosterbio-gene-info-cards/HDAC8
References
PMID: 10748112 by Hu E., et al. Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor.
PMID: 10926844 by Buggy J.J., et al. Cloning and characterization of a novel human histone deacetylase, HDAC8.