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- Table of Contents
HLTF Antibodies
AND HLTF ELISA kits, HLTF Proteins
Many biological assays use antibodies to detect HLTF, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HLTF in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HLTF antibodies...
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HLTF Overview
Facts about Helicase-like transcription factor.
Helicase-like transcription factor (HLTF)
Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity).
These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein may bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.
Gene Information
| Human | |
|---|---|
| Gene Name: | HLTF |
| Uniprot: | Q14527 |
| Entrez: | 6596 |
Family
| Belongs to: |
|---|
| SNF2/RAD54 helicase family |
Alternative Names
DNA-binding protein/plasminogen activator inhibitor 1 regulator; EC 3.6.1; EC 3.6.4.-; EC 6.3.2.-; helicase-like transcription factor; HIP116ARING finger protein 80; HIP116matrix associated, actin dependent regulator of chromatin; RNF80SWI/SNF-related matrix-associated actin-dependent regulator of chromatinsubfamily A member 3; subfamily a, member 3; Sucrose nonfermenting protein 2-like 3; ZBU1
Molecular Weight
Mass (kDA):
113.929 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q24 |
| Sequence: | 3; NC_000003.12 (149030063..149086554, complement) |
Tissue Specificity
Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.
Subcellular Localizations
Cytoplasm. Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nuclear localization is stimulated by progesterone.
Diseases
- Malignant Neoplasms
- Neoplasms
- Colorectal Cancer
- Colorectal Neoplasms
- Carcinoma
- Carcinogenesis
- Malignant Tumor Of Colon
- Stomach Neoplasms
- Neoplasm Metastasis
- Adenocarcinoma
- Malignant Neoplasm Of Stomach
- Adenoma
- Malignant Squamous Cell Neoplasm
Interacting Proteins
- PCNA
- RAD18
- S100A10
- UBE2N
Pathways
- Methylation
- Dna Methylation
- Dna Repair
- Dna Hypermethylation
- Translesion Synthesis
- Chromatin Remodeling
- Postreplication Repair
- Gene Silencing
- Regulation Of Gene Expression
- Mating
- Dna Replication
- Error-prone Translesion Synthesis
- Atp-dependent Chromatin Remodeling
PTMs
- Methylation
- Ubiquitination
- Demethylation
Research Areas
- Cancer
- Cell Biology
- Chromatin Research
- Tumor Suppressors
- Ubiquitin Proteasome Pathway
- Zinc Finger
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HLTF
bosterbio.com/bosterbio-gene-info-cards/HLTF
References
PMID: 7876228 by Sheridan P.L., et al. Cloning of an SNF2/SWI2-related protein that binds specifically to the SPH motifs of the SV40 enhancer and to the HIV-1 promoter.
PMID: 8672239 by Ding H., et al. Characterization of a helicase-like transcription factor involved in the expression of the human plasminogen activator inhibitor-1 gene.