Hemicentin-1 Antibodies

AND HMCN1 ELISA kits, Hemicentin-1 Proteins

Many biological assays use antibodies to detect Hemicentin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Hemicentin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Hemicentin-1 antibodies...

We validate the specificity of these antibodies to Hemicentin-1 by testing them on tissues known to express HMCN1 positively and negatively. Browse below to find the HMCN1 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HMCN1 Infographic by Boster Bio

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HMCN1 Overview

Facts about Hemicentin-1.

Hemicentin-1 (HMCN1)

Promotes cleavage furrow maturation during cytokinesis in preimplantation embryos. May play a role in the design of glue and flexible epithelial cell junctions.

May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration. .

Gene Information

Human
Gene Name:	HMCN1
Uniprot:	Q96RW7
Entrez:	83872

Family

Belongs to:

No superfamily

Alternative Names

Hemicentin-1

Molecular Weight

Mass (kDA):
613.39 kDA

Genomic Context


Human

Location:	1q25.3-q31.1
Sequence:	1; NC_000001.11 (185734391..186190949)

Tissue Specificity

Isoform 1 and isoform 2 are expressed in skin fibroblasts and retinal pigment epithelium (RPE) cells (PubMed:14570714).

Subcellular Localizations

Secreted, extracellular space, extracellular matrix, basement membrane. Cytoplasm. Cell junction. Cleavage furrow. The antibody used to determine subcellular location does not distinguish between HMCN1 and HMCN2.

Diseases

Macular degeneration, age-related, 1 (ARMD1)

Interacting Proteins

ARMS2

PTMs

Disulfide bond

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HMCN1

References

PMID: 14570714 by Schultz D.W., et al. Analysis of the ARMD1 locus: evidence that a mutation in hemicentin-1 is associated with age-related macular degeneration in a large family.