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HMGN3 Antibodies
AND HMGN3 ELISA kits, HMGN3 Proteins
Many biological assays use antibodies to detect HMGN3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HMGN3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HMGN3 antibodies...
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HMGN3 Infographic by Boster Bio
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HMGN3 Overview
Facts about High mobility group nucleosome-binding domain-containing protein 3.
High mobility group nucleosome-binding domain-containing protein 3 (HMGN3)
Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic enzymes involved in insulin secretion.
Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and other transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site.
Gene Information
| Human | |
|---|---|
| Gene Name: | HMGN3 |
| Uniprot: | Q15651 |
| Entrez: | 9324 |
Family
| Belongs to: |
|---|
| HMGN family |
Alternative Names
DKFZp686E20226; high mobility group nucleosomal binding domain 3; high mobility group nucleosome-binding domain-containing protein 3; high-mobility group protein HMGN3; PNAS-25; thyroid hormone receptor interacting protein 7; thyroid hormone receptor interactor 7; Thyroid receptor-interacting protein 7; TR-interacting protein 7; TRIP-7; TRIP7FLJ42187
Molecular Weight
Mass (kDA):
10.666 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6q14.1 |
| Sequence: | 6; NC_000006.12 (79201245..79234682, complement) |
Tissue Specificity
Expressed in kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate and uterus. Low expression in liver, spleen, placenta and ovaries.
Subcellular Localizations
Nucleus.
Diseases
- Neuroblastoma
- Anxiety Disorders
- Liver Carcinoma
- Malignant Neoplasm Of Breast
- Dystonia Disorders
- Diabetes Mellitus
- Carcinoma
- Epilepsy
- Diabetes Mellitus, Non-insulin-dependent
- Lissencephaly
- Fracture
Pathways
- Glucose Homeostasis
- Secretion
- Transport
- Insulin Secretion
- Localization
- Cell Maturation
- Translation
- Histone Acetylation
- Cell Growth
PTMs
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HMGN3
bosterbio.com/bosterbio-gene-info-cards/HMGN3
References
PMID: 7776974 by Lee J.W., et al. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor.
PMID: 12033773 by Leong P.W., et al. Differential display RT-PCR analysis of enterovirus-71-infected rhabdomyosarcoma cells reveals mRNA expression responses of multiple human genes with known and novel functions.