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- Table of Contents
Serine protease hepsin Antibodies
AND HPN ELISA kits, Serine protease hepsin Proteins
Many biological assays use antibodies to detect Serine protease hepsin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Serine protease hepsin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Serine protease hepsin antibodies...
Designing an IHC experiment for Serine protease hepsin? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the HPN IHC GuideHPN Infographic by Boster Bio
All HPN Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A02350-1
100 μg/vial
Cat # A02350-1
100 μg/vial
HPN Overview
Facts about Serine protease hepsin.
Serine protease hepsin (HPN)
Serine protease that cleaves extracellular substrates, and leads to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:21875933, PubMed:15839837). Plays a role in cell growth and maintenance of cell morphology (PubMed:8346233, PubMed:21875933).
Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890).
Gene Information
| Human | |
|---|---|
| Gene Name: | HPN |
| Uniprot: | P05981 |
| Entrez: | 3249 |
Family
| Belongs to: |
|---|
| peptidase S1 family |
Alternative Names
EC 3.4.21; EC 3.4.21.106; Hepsin; HPN; serine protease hepsin catalytic chain; serine protease hepsin; TMPRSS1 ; TMPRSS1serine protease hepsin non-catalytic chain; Transmembrane protease serine 1; transmembrane protease, serine 1
Molecular Weight
Mass (kDA):
45.011 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.11 |
| Sequence: | 19; NC_000019.10 (35040506..35066573) |
Tissue Specificity
Detected in liver and kidney.
Subcellular Localizations
Cell membrane; Single-pass type II membrane protein. Apical cell membrane; Single-pass type II membrane protein.
Diseases
- Malignant Neoplasms
- Short Bowel Syndrome
- Neoplasms
- Intestinal Diseases
- Systemic Infection
- Infective Disorder
- Crohn Disease
- Malabsorption Syndrome
- Malnutrition
- Liver Diseases
- Intestinal Obstruction
- Thrombosis
Pathways
- Excretion
- Intestinal Absorption
- Pathogenesis
- Aging
- Secretion
- Transport
- Flight
- Urea Cycle
- Translation
- Plasminogen Activation
- Conjugation
- Regeneration
- Fatty Acid Oxidation
PTMs
- Ubiquitination
- Demethylation
- Phosphorylation
Research Areas
- Cancer
- Prostate Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HPN
bosterbio.com/bosterbio-gene-info-cards/HPN
References
PMID: 2835076 by Leytus S.P., et al. A novel trypsin-like serine protease (hepsin) with a putative transmembrane domain expressed by human liver and hepatoma cells.
PMID: 1885621 by Tsuji A., et al. Hepsin, a cell membrane-associated protease. Characterization, tissue distribution, and gene localization.