Histamine H3 receptor (HRH3)

The H3 subclass of histamine receptors could mediate the histamine signs in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and exhibits high constitutive activity (spontaneous activity in the absence of agonist).

Agonist stimulation of isoform 3 modified adenylate cyclase activity nor induced intracellular calcium mobilization. .