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- Table of Contents
1 Citations
Facts about Histamine H3 receptor.
Agonist stimulation of isoform 3 modified adenylate cyclase activity nor induced intracellular calcium mobilization. .
| Human | |
|---|---|
| Gene Name: | HRH3 |
| Uniprot: | Q9Y5N1 |
| Entrez: | 11255 |

| Belongs to: |
|---|
| G-protein coupled receptor 1 family |

GPCR97; GPCR97G protein-coupled receptor 97; G-protein coupled receptor 97; H3R; HH3R; Histamine H3 R; histamine H3 receptor; Histamine H3R; histamine receptor H3; HRH3
Mass (kDA):
48.671 kDA

| Human | |
|---|---|
| Location: | 20q13.33 |
| Sequence: | 20; NC_000020.11 (62213845..62220278, complement) |
Expressed predominantly in the CNS, with the greatest expression in the thalamus and caudate nucleus. The various isoforms are mainly coexpressed in brain, but their relative expression level varies in a region-specific manner. Isoform 3 and isoform 7 are highly expressed in the thalamus, caudate nucleus and cerebellum while isoform 5 and isoform 6 show a poor expression. Isoform 5 and isoform 6 show a high expression in the amygdala, substantia nigra, cerebral cortex and hypothalamus. Isoform 7 is not found in hypothalamus or substantia nigra.
Cell membrane; Multi-pass membrane protein.





PMID: 10347254 by Lovenberg T.W., et al. Cloning and functional expression of the human histamine H3 receptor.
PMID: 11118334 by Nakamura T., et al. Molecular cloning and characterization of a new human histamine receptor, HH4R.