Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1)

Catalyzes the transfer of sulfate to the C2-position of chosen hexuronic acid residues within the aging heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is vital for HS to take part in a variety of high- affinity ligand-binding interactions and signaling processes.

Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity). .